Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis.

By M. F. Holick. American Journal of Clinical Nutrition, 2004

1,788 citations recorded by the source corpus.

Subfields: Nutrition and Dietetics, Orthopedics and Sports Medicine, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/e090ca1310ac6cb7e8baa81eac0e094db9929ad6

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Citations in the corpus

Human skin pigmentation as an adaptation to UV radiation (2010, background): “The roles of vitaminD3 in the regulation of intestinal calcium absorption, and in bone formation and remodeling, havebeenknown fordecades, but only recently has the importanceof vitaminD3 in the establishment andmaintenance of innate immunity, and in the normal functioning of the pancreas, brain, an”
Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. (2004, neutral): “The only way to determine whether a person is vitamin D (vitamin D represents either vitamin D2 or vitamin D3) sufficient, deficient, or intoxicated is to measure the circulating concentrations of 25(OH)D (2, 3, 22).”
The vitamin D epidemic and its health consequences. (2005, background): “PTH also decreases the gene expression of osteoprotegerin (a RANKL-like receptor that acts as a decoy) in osteoblasts, which further enhances osteoclastogenesis (25).”
Resurrection of vitamin D deficiency and rickets. (2006, neutral): “25 (OH)D is bound to DBP, and this complex binds to megalin on the plasma membrane of the renal tubule cell and is transported into the cell (20, 22).”
Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. (2011, background): “the risk for vitamin D deficiency (3, 31, 39, 103).”
Maternal intake of vitamin D during pregnancy and risk of recurrent wheeze in children at 3 y of age. (2007, background): “Recent studies suggest that vitamin D may have value in preventing or treating cancer and autoimmune diseases (2, 3).”
The epidemiology of vitamin D and cancer incidence and mortality: A review (United States) (2005, background): “Skin in the elderly has a markedly decreased capacity to produce vitamin D [39].”
Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis. (2006, background): “Because food provides little vitamin D, the major source for most people is through skin exposure to sunlight.(11) At latitudes of 42° or more (eg, Boston, Mass), in winter most UV-B radiation is absorbed by the atmosphere, and even prolonged sun exposure is insufficient to generate vitamin D.”
The nonskeletal effects of vitamin D: an Endocrine Society scientific statement. (2012, background): “There is also strong evidence that 1,25- (OH)2D modulates intracellular ionized calcium signaling in the adipocyte, which in turn promotes increased lipogenesis and decreased lipolysis, possibly through the inhibition of uncoupling protein-2 (UCP2) (92, 100).”
Vitamin D—Effects on Skeletal and Extraskeletal Health and the Need for Supplementation (2013, background): “As a decrease in 25(OH)D leads to secondary hyperparathyroidism associated with osteoclastogenesis and an increase in bone resorption exceeding osteoblast-mediated bone formation [88], this can precipitate and exacerbate osteopenia and osteoporosis in adults [17,92,93].”