Resurrection of vitamin D deficiency and rickets.

By M. F. Holick. Journal of Clinical Investigation, 2006

1,464 citations recorded by the source corpus.

Subfields: Nutrition and Dietetics, Orthopedics and Sports Medicine, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/8100363fa56695c4d878e1970823eb586b6d22f4

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Nutrition and Dietetics

1. M. F. Holick
2. M. Wacker
3. A. Ascherio
4. K. Munger
5. A. Hossein-Nezhad
6. C. Rosen
7. M. H. Murad
8. R. Nair

In Orthopedics and Sports Medicine

1. M. F. Holick
2. M. Wacker
3. A. Hossein-Nezhad
4. C. Rosen
5. R. Nair
6. A. Maseeh
7. M. H. Murad
8. A. Ascherio

In Pathology and Forensic Medicine

1. M. F. Holick
2. M. Wacker
3. K. Munger
4. A. Ascherio
5. A. Hossein-Nezhad
6. C. Rosen
7. R. Nair
8. A. Maseeh

Citations in the corpus

• Vitamin D deficiency: a worldwide problem with health consequences. (2008, background): “The major source of vitamin D for humans is exposure to sunlight (4, 8, 10).”
• Environmental risk factors for multiple sclerosis. Part II: Noninfectious factors (2007, background): “Serum levels of 25(OH)D are commonly used to measure vitamin D status for clinical and research purposes because serum levels of 1,25(OH)2D, the active form of vitamin D, are tightly regulated and within reference range even in vitamin D deficiency.(33) In contrast, 25(OH)D levels are sensitive to b”
• Sunlight and Vitamin D (2013, methodology): “Legislation quickly followed banning the fortification of any food or personal use products with vitamin D in Great Britain.(8,17,22) This ban quickly spread across Europe and for the most part remains in effect today with the exception of a few foods including margarine and some cereals being forti”
• Vitamin D status: measurement, interpretation, and clinical application. (2009, background): “The preferred level for 25(OH)D is now recommended by many experts to be O30 ng/mL (1, 4, 28).”
• Vitamin D2 is as effective as vitamin D3 in maintaining circulating concentrations of 25-hydroxyvitamin D. (2008, background): “as effective as vitamin D3 for bone health (3, 7).”
• Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic review and meta-analysis (2012, background): “We consider this study to be a key investigation because of the widespread perception that ergocalciferol and cholecalciferol are equally efficacious in their respective abilities to raise serum 25(OH)D concentrations (21).”
• The nonskeletal effects of vitamin D: an Endocrine Society scientific statement. (2012, background): “of helix 12 from an open position to a closed position, covering the ligand-binding pocket and putting helix 12 in position with critical residues from helices 3, 4, and 5 to bind coactivators (14).”
• Food system strategies for preventing micronutrient malnutrition (2013, background): “It has been reported that 80–90% of children in Boston, USA and Leiden, the Netherlands suffered from rickets in the late 19th century (Holick, 2006).”
• Vitamin D for Health: A Global Perspective (2013, positive): “Respiratory Tract Diseases and Wheezing Disorders At the turn of the past century, children with rickets were at higher risk for upper respiratory tract infections and for dying of them.(26,183) Macrophages have a VDR, andwhen they ingest an infectious agent, such as tuberculosis bacillus, the toll-”
• Vitamin D: The “sunshine” vitamin (2012, background): “[45,46] VDD also causes muscle weakness; affected children have difficulty in standing and walking,[46,47] whereas the elderly have increasing sway and more frequent falls,[48,49] thereby increasing their risk of fracture.”
• Vitamin D—Effects on Skeletal and Extraskeletal Health and the Need for Supplementation (2013, background): “In the 1930s, the fortification of milk, sodas, bread and even beer became popular [26]; however, after several cases of presumed vitamin D intoxication in infants in the 1950s in Great Britain [27] strict regulations limiting vitamin D fortification to only margarine were introduced in Europe [14,2”
• Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. (2011, background): “Vitamin D deficiency also causes muscle weakness; affected children have difficulty standingandwalking (47,50),whereas theelderlyhave increasing sway and more frequent falls (51, 52), thereby increasing their risk of fracture.”
• Factors that influence the cutaneous synthesis and dietary sources of vitamin D. (2007, background): “Since the sunlight spectrum (UVB radiation) responsible for the synthesis of previtamin D3 also increases risk of skin cancers (1,22), dietary supplementation of vitamin D is advisable in order to prevent vitamin D-deficiency, especially elderly and highly pigmented skin individuals who will not be ”
• Vitamin D supplementation guidelines. (2018, background): “25(OH)D-1a-hydroxylase kinetics and the results of numerous meta-analyzes, RCTs, and observational studies provide convincing data that a target 25(OH)D concentration likely to meet requirements of human tissues containing vitamin D receptor (VDR) is approximately 40 ng/mL (100 nmol/L) [5,7,9,28,32,”
• Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects. (2016, background): “Melanin and sunscreen markedly diminish the production of vitamin D (194, 483).”
• UV Radiation and the Skin (2013, background): “In fact, UV doses that induce tanning far exceed what is required for adequate vitamin D production and the widespread availability of vitamin D in supplements and fortified foods minimizes the need for UV exposure to avoid symptoms of rickets and vitamin D deficiency [70–74].”