Vitamin D—Effects on Skeletal and Extraskeletal Health and the Need for Supplementation
By M. Wacker, M. F. Holick. Nutrients, 2013
714 citations recorded by the source corpus.
Vitamin D, the sunshine vitamin, has received a lot of attention recently as a result of a meteoric rise in the number of publications showing that vitamin D plays a crucial role in a plethora of physiological functions and associating vitamin D deficiency with many acute and chronic illnesses including disorders of calcium metabolism, autoimmune diseases, some cancers, type 2 diabetes mellitus, cardiovascular disease and infectious diseases. Vitamin D deficiency is now recognized as a global pandemic. The major cause for vitamin D deficiency is the lack of appreciation that sun exposure has been and continues to be the major source of vitamin D for children and adults of all ages. Vitamin D plays a crucial role in the development and maintenance of a healthy skeleton throughout life. There remains some controversy regarding what blood level of 25-hydroxyvitamin D should be attained for both bone health and reducing risk for vitamin D deficiency associated acute and chronic diseases and how much vitamin D should be supplemented.
Subfields: Nuclear and High Energy Physics, Radiation
View Paper: https://www.semanticscholar.org/paper/6a162686f46a2ab3be52374c007adf0eceb53fd4
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Citations in the corpus
- Vitamin D and Immune Function (2013, background): “Very few natural, non-fortified products such as fatty fish (salmon, mackerel, sardines, cod liver oil) or some types of mushrooms (Shiitake), especially if sundried, contain relevant amounts of one of the two major forms, cholecalciferol (vitamin D3) or ergocalciferol (vitamin D2) [7,11,12].”
- Vitamin D supplementation guidelines. (2018, background): “Some patients who have tertiary hyperparathyroidism due to chronic vitamin D deficiency or chronic renal failure can often benefit with reduction in their serum PTH and calcium by treatment with vitamin D to achieve 25(OH)D concentration of at least 30 ng/mL (75 nmol/L) [93].”