Mechanisms of Hair Graying: Incomplete Melanocyte Stem Cell Maintenance in the Niche

By E. Nishimura, S. Granter, D. Fisher. Science, 2005

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Mitf regulation of Dia1 controls melanoma proliferation and invasiveness. (2006, background): “1997) and postnatal melanocyte stem cells (Nishimura et al. 2005).”
Stems cells and the pathways to aging and cancer. (2008, background): “For example, graying of hair, one of the most recognizable aspects of human aging, appears to result from an age-dependent loss of melanocyte stem cells (MSCs) from the subcutaneous hair follicle bulge region (Nishimura et al., 2005) and may be exacerbated by telomere dysfunction as suggested by the”
Characterization and isolation of stem cell-enriched human hair follicle bulge cells. (2005, background): “In addition, although keratinocytes predominate in the bulge, other cell types such as melanocyte stem cells (27) or Merkel cells (28) are also reported to reside in this area, and upregulation of a gene in bulge ORS could reflect highly elevated gene transcription in non-keratinocytes.”
Skin melanocytes: biology and development (2013, background): “What do we know about the presence of melanoblasts in the adult skin? The first documented reservoir for melanocyte stem cells was the bulge area of the hair follicles either in the mouse or human [78, 79].”
How stem cells age and why this makes us grow old (2007, background): “Likewise, hair greying has been linked to decreased melanocyte stem-cell maintenance, possibly in association with melanoblast senescenc”