Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivity

By O. Akbari, P. Stock, E. Meyer, M. Kronenberg, S. Sidobre, T. Nakayama, Masaru Taniguchi, M. Grusby, R. DeKruyff, D. Umetsu. Nature Medicine, 2003

744 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Going both ways: immune regulation via CD1d-dependent NKT cells. (2004, background): “are required for the induction of airway sensitivity (119, 120).”
Interleukin‐13 in asthma pathogenesis (2004, background): “(4) have recently demonstrated that natural killer T cells may be an important source of IL-13 early in the allergic response, although the ligand for their activation is not currently known.”
How are TH2-type immune responses initiated and amplified? (2010, background): “A report showed that NKT cells were essential for allergen-induced AHR but were not required for T H 2 cell differentiation in this model, implying that they orchestrate or mediate the effector response rather than T H 2 cell inductio”
The biology of NKT cells. (2007, background): “CD1d- and Jα18-deficient mice were reported to exhibit decreased allergeninduced airway hyperreactivity in the alumovalbumin model of asthma, where mice are intraperitoneally sensitized with ovalbumin mixed in alum and subsequently challenged with ovalbumin inhalation (238, 239).”
Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity (2011, background): “Moreover, unlike AHR induced by allergens, ozone or Sendai virus, which requires NKT cell”