Phenotypic consequences of promoter-mediated transcriptional noise.

By William J. Blake, G. Balázsi, Michael A. Kohanski, Farren J. Isaacs, K. F. Murphy, Y. Kuang, C. Cantor, D. Walt, James J. Collins. Molecules and Cells, 2006

642 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/df7afe27d164f92e91a68335292b72bc319e4f00

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Citations in the corpus

MicroRNA-mediated feedback and feedforward loops are recurrent network motifs in mammals. (2007, background): “The eukaryotic cell is a noisy environment in which transcription often occurs in a bursting manner (Blake et al., 2006; Golding et al., 2005; Raj et al., 2006), causing the number of mRNAs per cell— which can go as low as fractions of a copy when averaged over a population—to fluctuate significantl”
Roles for microRNAs in conferring robustness to biological processes. (2012, neutral): “Transcription occurs in stochastic bursts (Blake et al., 2006; Raj et al., 2006), and higher transcription rates correlate with lower noise (Paulsson, 2004).”
Cellular Decision-Making and Biological Noise: From Microbes to Mammals (2011, background): “Recent experiments confirmed these predictions, showing that noise can aid survival in severe stress (Blake et al., 2006), can optimize the efficiency of resource uptake during starvation (Ça gatay et al.”
Stochastic gene expression and its consequences (2008, background): “Almost immediately, several reports seemed to indicate that the sources of variability in gene expression in yeast are different from those in bacteria in a number of important ways (Becskei et al., 2005; Blake et al., 2006; Blake et al., 2003; Raser and O’Shea, 2004).”
Tuning gene expression to changing environments: from rapid responses to evolutionary adaptation (2008, background): “Several recent studies indicate that noise levels are tuned by evolution to balance fidelity and variation of gene expression; although too much noise with respect to the regulation of processes such as cell proliferation or development could be detrimental for fitness, variable regulation of enviro”
Stochastic switching as a survival strategy in fluctuating environments (2008, background): “Recent work suggests that in an adverse environment, cell-to-cell variability can have an impact on the fitness of a populatio”