Stochastic switching as a survival strategy in fluctuating environments
By M. Acar, Jerome T. Mettetal, Alexander van Oudenaarden. Nature Genetics, 2008
918 citations recorded by the source corpus.
Subfields: Genetics, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/cae6e7082c42f26593abac62cc7edd9b331aa7d8
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Genetics
In Molecular Biology
- Alexander van Oudenaarden
- Arjun Raj
- G. Balázsi
- James J. Collins
- Stefan Bornholdt
- R. Zenobi
- John C. Marioni
- Santo Fortunato
Citations in the corpus
- Single-Cell Metabolomics: Analytical and Biological Perspectives (2013, background): “of minutes to hours (11), the metabolome reacts to environmental influences on a time scale of”
- Cellular Decision-Making and Biological Noise: From Microbes to Mammals (2011, background): “, 2009), and can optimize survival in specific fluctuating environments (Acar et al., 2008).”
- Boolean network models of cellular regulation: prospects and limitations (2008, background): “While in general this is a rather exotic phenomenon in regulatory networks (Acar et al. 2008), it may be relevant in specific circumstances (for example, cell differentiation).”
- Stochastic gene expression and its consequences (2008, background): “Experimentally, Acar et al. (2008) tested these theories by monitoring the growth rate of a yeast strain with a controllable rate of switching in a periodically fluctuating environment and show that fast switchers do indeed grow faster in rapidly fluctuating environments whereas slow switchers do…”
- Roles for microRNAs in conferring robustness to biological processes. (2012, neutral): “A tumor may be analogous to a clonal population of bacteria or yeast in which noise in the population adapts them to unpredictably changing environmental conditions (Acar et al., 2008; Ca gatay et al., 2009).”
- Tuning gene expression to changing environments: from rapid responses to evolutionary adaptation (2008, background): “cerevisiae suggests that cells might tune the rate of stochastic switching between different phenotypes to the frequency of environmental fluctuations in order to optimize surviva”