IL-15Rα expression on CD8+ T cells is dispensable for T cell memory

By Patrick R. Burkett, R. Koka, Marcia Chien, Sophia Chai, Faye Chan, A. Ma, D. Boone. Proceedings of the National Academy of Sciences of the United States of America, 2003

160 citations recorded by the source corpus.

Subfields: Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/defd52b989ab7c0d8c96797ea49593e073e10164

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. M. Bevan
2. Matthew A. Williams
3. Joseph C. Sun
4. A. Ma
5. C. Pickart
6. T. Malek
7. E. Wherry
8. I. Castro

In Oncology

1. M. Bevan
2. C. Pickart
3. Donna D. Zhang

Citations in the corpus

• CD4+ T cells are required for the maintenance, not programming, of memory CD8+ T cells after acute infection (2004, background): “Expression of the high affinity IL-15Rα on the CD8 + T cells themselves is dispensable for CD8 memory, although binding of IL-15 to the low-affinity receptor composed of the IL-15Rβ and the γ c subunits on memory CD8 + T cells is required for their maintenanc”
• The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses (2004, methodology): “Flow cytometric analyses of tissues from mice were done as describe”
• Cutting Edge: Murine Dendritic Cells Require IL-15Rα to Prime NK Cells1 (2004, background): “Although such indirect roles for IL-15R could involve multiple cell types, experiments with radiation chimera suggest that IL-15R expression on hemopoietic cells may be more important than nonhemopoietic cells in supporting both CD8 memory T cells and NK cells (15, 16).”
• New insights into the regulation of T cells by γc family cytokines (2009, unknown): “Indeed, under physiological conditions, trans -presentation of IL-15 by IL-15Rα on the surface of other non-T cells is require”