Regulation of GPCRs by endocytic membrane trafficking and its potential implications.

By A. Hanyaloglu, M. von Zastrow. Annual Review of Pharmacology and Toxicology, 2008

621 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Endocytosis and signalling: intertwining molecular networks (2009, neutral): “Although recycling has been considered a default cargo route from endosomes, it is now established that specific sequence motifs and specific interactions control the recycling of some signalling receptor”
Teaching old receptors new tricks: biasing seven-transmembrane receptors (2010, background): “The prolonged association of β-arrestins with the receptor is thought to inhibit 7TMR resensitization, although other evidence argues for different mechanisms regulating receptor recycling (reviewed in Ref”
The delivery of therapeutic oligonucleotides (2016, background): “The signaling activity of GPCRs is tightly linked with their endocytosis and intracellular trafficking (96).”
The structure and function of G-protein-coupled receptors (2009, background): “Similarly, the process of GPCR desensitization involves multiple pathways, including receptor phosphorylation events, arrestin-mediated internalization into endosomes, receptor recycling and lysosomal degradatio”