Insulin-regulated hepatic gluconeogenesis through FOXO1–PGC-1α interaction
By P. Puigserver, James Rhee, Jerry Donovan, C. Walkey, J. C. Yoon, F. Oriente, Y. Kitamura, J. Altomonte, Hengjiang Dong, D. Accili and 1 more. Nature, 2003
1,372 citations recorded by the source corpus.
Subfields: Molecular Biology, Physiology
View Paper: https://www.semanticscholar.org/paper/de6ec2ff0fcae04e53f3df8b7cd2de2c84a1110b
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Molecular Biology
- M. Sandri
- David M. Sabatini
- R. Scarpulla
- B. Spiegelman
- S. Schiaffino
- Christoph Handschin
- P. Bonaldo
- C. Mammucari
In Physiology
- R. Scarpulla
- B. Spiegelman
- Johan Auwerx
- Christoph Handschin
- Jiandie D. Lin
- M. Sandri
- C. Cantó
- S. Schiaffino
Citations in the corpus
- Cellular and molecular mechanisms of muscle atrophy (2013, background): “FoxO has been found to interact with PGC1α, a critical cofactor for mitochondrial biogenesis (Puigserver et al., 2003; Wu et al., 1999).”
- The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways. (2010, background): “This increase in NAD content correlates with increased SIRT1mediated deacetylation and activation of the coactivator PGC-1 (82), which then promotes gluconeogenesis by coactivating a set of transcription factors, including hepatocyte nuclear factor-4 (104), glucocorticoid receptor (105), and FOXOs (”
- mTOR: from growth signal integration to cancer, diabetes and ageing (2010, background): “When glucose is abundant, insulin signalling through Akt suppresses the expression of phosphoenolpyruvate carboxykinase (PEPCK), a transcriptional target of FOXO1 that is the limiting enzyme of gluconeogenesis in the live”
- The nuts and bolts of AGC protein kinases (2010, background): “Moreover, Akt controls blood glucose levels by regulating hepatic glucose output and metabolism by phosphorylating various transcriptional regulators, including FOXO and PPARγ coactivator 1&alpha”
- Mechanisms regulating skeletal muscle growth and atrophy (2013, background): “148 Puigserver P, Rhee J, Donovan J, Walkey CJ, Yoon JC, Oriente F, Kitamura Y, Altomonte J, Dong H, Accili D, et al. (2003) Insulin-regulated hepatic gluconeogenesis through FOXO1–PGC-1a interaction.”
- Trends in insulin resistance: insights into mechanisms and therapeutic strategy (2022, background): “In addition, the transcription factor forkhead box O1 (FOXO1) is phosphorylated by AKT and is transported from the nucleus, thereby disabling its transcription factor activity and inhibiting gluconeogenesis.(27,28) (2) Tuberous sclerosis complex 1/ 2 (TSC1/2) and proline-rich Akt substrate 40 (PRAS4”
- Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor Foxo1 in liver. (2007, methodology): “The forkhead transcription factor Foxo1 confers insulin responsiveness onto G6pc expression (Nakae et al., 2001) by interacting with Pgc1a (Puigserver et al., 2003).”