Helicobacter pylori and interleukin 1 genotyping: an opportunity to identify high-risk individuals for gastric carcinoma.

By C. Figueiredo, J. Machado, P. Pharoah, R. Seruca, S. Sousa, R. Carvalho, A. F. Capelinha, W. Quint, Carlos Caldas, L. van Doorn and 2 more. Journal of the National Cancer Institute, 2002

661 citations recorded by the source corpus.

Subfields: Epidemiology, Pathology and Forensic Medicine, Surgery

View Paper: https://www.semanticscholar.org/paper/de047cf71727eee4126a466252061a9b08dbae54

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. Martin J. Blaser
2. R. Peek

In Pathology and Forensic Medicine

1. Martin J. Blaser

In Surgery

1. Martin J. Blaser
2. P. Lehours
3. R. Peek
4. Keith T. Wilson
5. E. Kuipers
6. Lydia E. Wroblewski

Citations in the corpus

• Overexpression of interleukin-1beta induces gastric inflammation and cancer and mobilizes myeloid-derived suppressor cells in mice. (2008, background): “, 2003), particularly gastric cancer (El-Omar et al., 2001; Figueiredo et al., 2002).”
• Helicobacter pylori and Gastric Cancer: Factors That Modulate Disease Risk (2010, background): “pylori vacA s1-type strains, the relative risk for gastric cancer was 87-fold over baseline (94), indicating that interactions between specific host and microbial characteristics are biologically significant for the development of gastric cancer.”
• Increased risk of noncardia gastric cancer associated with proinflammatory cytokine gene polymorphisms. (2003, neutral): “IL-1B-511 C/C 21 (40) 50 (46) 57 (45) 47 (25) 104 (50) C/T 21 (40) 46 (43) 56 (44) 98 (52) 97 (46) T/T 11 (20) 12 (11) 13 (11) 43 (23) 9 (4) IL-1RN 1/1 30 (57) 49 (46) 69 (55) 81 (43) 114 (55) 1/2 12 (23) 40 (37) 42 (33) 59 (31) 76 (36) 1/3,4 2 (3) 10 (9) 3 (2) 2 (1) 7 (3) 2/2 8 (15) 8 (7) 12 (10) 4”
• Microbiome and Malignancy (2011, background): “Particular host polymorphisms that relate to innate immunity (e.g. affecting IL-1, IL-1RA, and TNF-α expression) enhance the risk of gastric cancer associated with H. pylori positivity (El-Omar et al., 2001; El-Omar et al., 2003; Figueiredo et al., 2002).”
• Helicobacter pylori Detection and Antimicrobial Susceptibility Testing (2007, background): “For example, a combination of cag PAI-positive strains and certain alleles of interleukin-1 of the host considerably increases the risk of gastric carcinoma (143).”
• Management of precancerous conditions and lesions in the stomach (MAPS): guideline from the European Society of Gastrointestinal Endoscopy (ESGE), European Helicobacter Study Group (EHSG), European Society of Pathology (ESP), and the Sociedade Portuguesa de Endoscopia Digestiva (SPED) (2011, positive): “It is believed that the combination of a virulent organism in a genetically susceptible host is associated with more severe chronic inflammation and more rapid progression to gastric cancer, at least for Lauren ’ s intestinal type [182 – 184].”