Increased risk of noncardia gastric cancer associated with proinflammatory cytokine gene polymorphisms.

By E. El-Omar, C. Rabkin, M. Gammon, T. Vaughan, H. Risch, J. Schoenberg, J. Stanford, S. Mayne, J. Goedert, W. Blot and 2 more. Gastroenterology, 2003

955 citations recorded by the source corpus.

Subfields: Immunology, Surgery

View Paper: https://www.semanticscholar.org/paper/e1c39525a1095fe195fc4da039a9fdccf6b0bb1b

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. R. Peek
2. Keith T. Wilson
3. Lydia E. Wroblewski
4. E. Kuipers
5. A. V. van Vliet
6. J. G. Kusters
7. Martin J. Blaser
8. Masanori Hatakeyama

In Surgery

1. R. Peek
2. Martin J. Blaser
3. Keith T. Wilson
4. Lydia E. Wroblewski
5. E. Kuipers
6. A. V. van Vliet
7. J. G. Kusters
8. Masanori Hatakeyama

Citations in the corpus

• iArc monogrAphs on the evAluAtion oF cArcinogenic risks to humAns (2012, background): “One of these (El Omar et al., 2003) included 53 cases and reported a statistically significant increased odds ratio of 2.”
• Microbiome and Malignancy (2011, background): “Particular host polymorphisms that relate to innate immunity (e.g. affecting IL-1, IL-1RA, and TNF-α expression) enhance the risk of gastric cancer associated with H. pylori positivity (El-Omar et al., 2001; El-Omar et al., 2003; Figueiredo et al., 2002).”
• Helicobacter pylori: gastric cancer and beyond (2010, background): “Polymorphisms in the human IL1B gene promoter that are associated with increased expression of IL-1β (a pro-inflammatory cytokine with potent acid-suppressive properties) heighten the risk for atrophic gastritis and gastric adenocarcinom”
• Oncogenic mechanisms of the Helicobacter pylori CagA protein (2004, background): “pylori infection might therefore be strongly influenced by host genetic polymorphisms, such as those that determine the ability to induce pro-inflammatory cytokines that regulate gastric-acid secretio”
• Helicobacter pylori and Gastric Cancer: Factors That Modulate Disease Risk (2010, background): “The combinatorial effect of IL-1 , TNF- , and IL-10 polymorphisms on the development of cancer has also been determined, and risk increases progressively with an increasing number of proinflammatory polymorphisms, to the point that three high-risk polymorphisms increase the risk of cancer 27fold ove”
• Cytokines in Cancer Immunotherapy (2011, background): “this cytokine may play a critical role in some aspect of tumor immunosurveillance [168,169].”
• Pathogenesis of Helicobacter pylori Infection (2006, background): “levels and a shift toward a proinflammatory response (159, 250, 264, 377, 515, 697, 714).”
• Age and Age-Related Diseases: Role of Inflammation Triggers and Cytokines (2018, background): “In addition, IL-1β inhibits gastric acid secretion and carriers of IL-1β polymorphisms producing higher IL-1β carry increased gastric cancer risk (287, 288).”