Macrophages and Tissue Injury: Agents of Defense or Destruction?
By D. Laskin, V. Sunil, C. Gardner, J. Laskin. Annual Review of Pharmacology and Toxicology, 2011
608 citations recorded by the source corpus.
The past several years have seen the accumulation of evidence demonstrating that tissue injury induced by diverse toxicants is due not only to their direct effects on target tissues but also indirectly to the actions of resident and infiltrating macrophages. These cells release an array of mediators with cytotoxic, pro- and anti-inflammatory, angiogenic, fibrogenic, and mitogenic activity, which function to fight infections, limit tissue injury, and promote wound healing. However, following exposure to toxicants, macrophages can become hyperresponsive, resulting in uncontrolled or dysregulated release of mediators that exacerbate acute tissue injury and/or promote the development of chronic diseases such as fibrosis and cancer. Evidence suggests that the diverse activity of macrophages is mediated by distinct subpopulations that develop in response to signals within their microenvironment. Understanding the precise roles of these different macrophage populations in the pathogenic response to toxicants is key to designing effective treatments for minimizing tissue damage and chronic disease and for facilitating wound repair.
Subfields: Epidemiology, Immunology, Rehabilitation
View Paper: https://www.semanticscholar.org/paper/17f8ca5cf3b3a134670d103fa22539baba045b64
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Immunology
Citations in the corpus
- Reactive Oxygen Species in Inflammation and Tissue Injury (2014, unknown): “Among the commonly used inflammatory mediators used to simulate inflammation are included cytokines (e.g., TNF-a), the stress of hyperoxia, ischemia-reperfusion injury, bacterial toxins (LPS), and mediators that ligate cell surface receptors (PAF, thrombin, histamine, VEGF, and bradykinins).”
- The role of macrophages in the resolution of inflammation. (2019, background): “For almost a century, investigators have focused on the role of monocytes and macrophages in the acute response to tissue injury, where they are known to produce cytotoxic and proinflammatory mediators, clear invading microorganisms, remove apoptotic and damaged cells, and promote tumor progression ”
- Mesenchymal Stem Cells Secrete Immunologically Active Exosomes (2014, unknown): “The contrast in the induction of IL10 and IL12P40 genes by exosomes and LPS suggested that LPS induced an M1 macrophage-like phenotype, while MSC exosomes activated an M2 macrophage-like phenotype [38,39].”