Evolving functions of endothelial cells in inflammation

By J. Pober, W. Sessa. Nature reviews. Immunology, 2007

1,964 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/ddcda31a8f4b6e25f0ff8be334f090f67a6eab81

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. J. Zindel
2. P. Kubes
3. Peter Libby
4. A. Tall
5. Karin E. Bornfeldt
6. Christoph Borner
7. S. Verma
8. R. Alon

In Molecular Biology

1. J. Zindel
2. A. Ramachandran
3. P. Kubes
4. Christoph Borner
5. Peter Libby
6. H. Jaeschke
7. S. Verma
8. A. Tall

Citations in the corpus

• COVID-19 is, in the end, an endothelial disease (2020, background): “Positioned at the key interface between the blood and tissues, the endothelium normally resists prolonged contact with the leucocytes that abound in blood that bathes the intimal surface.(3,24) Stationed as the sentinel, the endothelium serves as the portal governing the entry”
• Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis (2016, positive): “A second important link between atherogenesis and proinflammatory endothelial activation is the intrinsic capacity of activated vascular cells (endothelium and smooth muscle) to secrete chemokines, such as IL-1, monocyte chemoattractant protein-1, granulocyte-monocyte stimulating factor, and IL-8, t”
• Angiotensin II revisited: new roles in inflammation, immunology and aging (2010, background): “Inflammation involves activation of the endothelium of blood vessels and expression of diverse endothelial cell selectins that dictate extravasation of specific leukocyte populations to the site of injury (Medzhitov & Horng, 2009; Pober & Sessa, 2007).”
• Circulating Platelets as Mediators of Immunity, Inflammation and Thrombosis (2018, background): “can increase endothelial permeability, as well as recruitment and attachment of leukocytes to the endothelium.(48,49) This leads to platelet alteration of the inflammatory cell transmigration to damaged or infected tissue.”
• Origin and physiological roles of inflammation (2008, background): “This selectivity is afforded by the inducible ligation of endothelial-cell selectins with integrins and chemokine receptors on leukocytes, which occurs at the endothelial surface, as well as in the extravascular spaces (where newly deposited plasma proteins form a provisional matrix for the binding ”
• Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME (2013, positive): “…peptide (NAM)) or damage-associated molecular patterns (DAMPs, e.g. DNA), (2) secretion of cytokines and chemokines to recruit and activate leukocytes and (3) expressing adhesion molecules that favor the attachment and extravasation of leukocytes to the site of injury (Pober and Sessa 2007).”
• Leukocyte migration into inflamed tissues. (2014, background): “Type II protein synthesis-dependent activation of endothelial cells can result in the expression of a variety of chemoattractants for myeloid leukocytes and effector T cells (Pober and Sessa, 2007).”
• DAMPs, PAMPs, and LAMPs in Immunity and Sterile Inflammation. (2020, background): “The fourth cardinal symptom,dolor (pain), is directly caused by inflammatorymediators onC-type sensory nerve fibers (35).”
• Endothelial cell control of thrombosis (2015, background): “Endothelial cells are dynamic and adapt their phenotype according to the nature of the local milieu [11, 12].”
• Pathophysiology of Atherosclerosis (2022, background): “Endothelial stimulation, also known as endothelial type I activation, occurs when inflammatory agents induce a response such as a change in microvascular tone, permeability, or leukocyte diapedesis [114,115].”
• Immunosuppression in Patients Who Die of Sepsis and Multiple Organ Failure (2011, neutral): “0) [24-84] Sex Male 17 Female 12 Admission diagnosis Motor vehicle collision, head trauma 1”