Close encounters of many kinds: Fos-Jun interactions that mediate transcription regulatory specificity

By Yurii Chinenov, T. Kerppola. Oncogene, 2001

737 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/dd824d9e181385604910059cb4d54ea0a29f43cf

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Citations in the corpus

Oxidative Stress and Oxidative Damage in Carcinogenesis (2010, background): “AP-1 is a collection of dimeric bZip proteins that belong to the Jun (c-Jun, JunB, JunD), Fos (FosB, Fra-1, Fra-2), Maf (musculoaponeurotic fibrosarcoma), and ATF (activating transcription factor) subfamilies, all of which can bind TPA or cAMP response elements (Chinenov and Kerppola 2001).”
Transcriptional regulation by calcium, calcineurin, and NFAT. (2003, background): “Classically, AP-1 consists of heterodimers of Fos- and Junfamily proteins: Fos proteins do not dimerize with one another, and Jun dimers bind DNA with lower affinity than Fos–Jun (Chinenov and Kerppola 2001; Jochum et al. 2001; Mechta-Grigoriou et al. 2001).”
Architecture of the human regulatory network derived from ENCODE data (2012, background): “The GM12878 and K562 cell lines have the most common (31) transcription factor data sets (Supplementary Information, section C.”
Gene expression profiling reveals the defining features of the classical, intermediate, and nonclassical human monocyte subsets. (2011, background): “These include JUN, FOS, ATF and MAF family members that dimerize through leucine zippers motifs.(31) Different heterodimers of these components define the transcription targets for AP-1.”
Molecular Mechanisms of Treg-Mediated T Cell Suppression (2012, background): “Various cytokine promoters, e.g., IL-2, IL-4, IL-5, IFN-γ, and TNF-α contain cooperative NFAT:AP-1 binding sites which greatly enhance transcription of the respective cytokine (Rao et al., 1997; Chinenov and Kerppola, 2001; Macian et al., 2001; Hermann-Kleiter and Baier, 2010).”
Crystal structure of ATF‐2/c‐Jun and IRF‐3 bound to the interferon‐β enhancer (2004, background): “For example, most composite NFAT–AP-1 regulatory elements contain nonconsensus AP-1 recognition elements (Chinenov and Kerppola, 2001; Macian et al, 2001).”