Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells.

By T. Hirota, Naoko Kunitoku, T. Sasayama, Tomotoshi Marumoto, Dongwei Zhang, M. Nitta, K. Hatakeyama, H. Saya. Cell, 2003

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Integrative genomic and proteomic analysis of prostate cancer reveals signatures of metastatic progression. (2005, background): “, 2004), play a key role in G2/M cell cycle progression (Hirota et al., 2003), and inhibit p53 (Katayama et al.”
Roles of Aurora Kinases in Mitosis and Tumorigenesis (2007, background): “Aurora-A is activated mainly by Ajuba (32) and TPX2 (42) as well as protein phosphatase inhibitor-2 (75), the focal scaffolding protein HEF1 (76), and a newly identified Bora protein (77).”
Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53 (2004, background): “Aurora kinase A has been implicated in regulating centrosome function, spindle assembly, spindle maintenance and mitotic commitment in cell”
Aurora-A — A guardian of poles (2005, background): “Also, in cultured human cells, Aurora-A depletion results in the inhibition of centrosome maturatio”
Shared and separate functions of polo-like kinases and aurora kinases in cancer (2010, background): “102 ), where aurora kinase A promotes the recruitment of cyclin B1 (Ref”
Aurora-kinase inhibitors as anticancer agents (2004, background): “Repression of Aurora-A expression by RNA interference (RNAi) delays mitotic entry in human cell”