Aurora-A — A guardian of poles

By Tomotoshi Marumoto, Dongwei Zhang, H. Saya. Nature Reviews. Cancer, 2005

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Kinase-targeted cancer therapies: progress, challenges and future directions (2018, background): “Aurora kinases are strategic kinases involved in defective spindle pole organization, and their pathophysiology correlates strongly with their oncogenic functions [46].”
Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines. (2006, background): “HCDC4, an E3 ubiquitin ligase, is reported to be involved in degradation of aurora kinase A (STK15 [AURKA]) (Mao et al., 2004; Marumoto et al., 2005; Yang et al., 2004).”
HEF1-dependent Aurora A activation induces disassembly of the primary cilium. (2007, neutral): “In humans, Aurora A (AurA) is a centrosomal kinase that regulates mitotic entry through activation of Cdk1-cyclin B and other substrates that organize the mitotic spindle (Bischoff et al., 1998; Marumoto et al., 2005).”