MAML1, a human homologue of Drosophila Mastermind, is a transcriptional co-activator for NOTCH receptors

By Lizi Wu, J. Aster, S. Blacklow, R. Lake, S. Artavanis-Tsakonas, J. Griffin. Nature Genetics, 2000

626 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

The ankyrin repeat as molecular architecture for protein recognition (2004, neutral): “MAML1 (Wu et al. 2000; Nam et al. 2003)”
Direct inhibition of the NOTCH transcription factor complex (2009, background): “Indeed, human NOTCH1 was first discovered owing to its involvement in a t(7;9) chromosomal translocation observed in patients with T-ALL(13).”
c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma. (2006, background): “…complex with a DNA-binding protein termed CSL (for CBF1, Suppressor of Hairless, Lag-1) (Jarriault et al. 1995; Kopan et al. 1996; Struhl and Greenwald 1999; Ye et al. 1999) and transcriptional coactivators of the Mastermind-like (MAML) family (Petcherski and Kimble 2000a,b; Wu et al. 2000).”
SHARP is a novel component of the Notch/RBP‐Jκ signalling pathway (2002, background): “The human homologue of Mastermind, MAML1, functions as a transcriptional coactivator by directly interacting with the ankyrin repeat domain of Notch (Wu et al., 2000) and by recruiting p300/CBP (Fryer et al., 2002).”
Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance (2005, background): “In association with the transcriptional coactivator mastermind-like 1 (MAML1”
Notch signaling in the mammalian central nervous system: insights from mouse mutants (2005, background): “The NICD/CBF1 activator complex, which includes the co-activator Mastermin”