SHARP is a novel component of the Notch/RBP‐Jκ signalling pathway
By F. Oswald, U. Kostezka, K. Astrahantseff, S. Bourteele, Karin Dillinger, U. Zechner, L. Ludwig, M. Wilda, H. Hameister, W. Knöchel and 2 more. 2002
252 citations recorded by the source corpus.
Subfields: Cancer Research, Molecular Biology
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In Cancer Research
In Molecular Biology
- Suzuka Mikami
- Yutaka Ito
- Christina S. Leslie
- Ayaho Kobayashi
- Stephan W. Morris
- T. Fujiwara
- N. Takizawa
- Haitao Li
Citations in the corpus
- Structural insights into the recruitment of SMRT by the corepressor SHARP under phosphorylative regulation. (2013, background): “SMRT/HDAC1-associated repressor protein (SHARP) is a transcriptional corepressor that was identified independently in nuclear receptor and Notch/RBP-Jk signaling pathways (Oswald et al., 2002; Shi et al., 2001).”
- Rbm15 Modulates Notch-Induced Transcriptional Activation and Affects Myeloid Differentiation (2007, background): “Protein alignments and structural domain predictions show little homology with known RBPJ interaction domains of other proteins, such as SHARP ( 38 ), the RTA protein of the Kaposi’s sarcoma-associated herpesvirus (29), the Epstein-Barr virus nuclear antigens 2 and 3 (16), and the Notch1 RAM domain ”
- A conserved structural motif reveals the essential transcriptional repression function of Spen proteins and their role in developmental signaling. (2003, background): “The human homolog of MINT, SHARP (SMRT/ HDAC1-associated repressor protein), has been identified as a component in transcriptional repression complexes recruited by both nuclear receptors and the Notch-signaling factor RBP-J (Shi et al. 2001; Oswald et al. 2002).”
- Cross-talk between PRMT1-mediated methylation and ubiquitylation on RBM15 controls RNA splicing (2015, background): “Spen proteins are evolutionally conserved 65 RNA binding proteins, which are involved in transcriptional regulation of NOTCH, WNT and MAPK signal 66 transduction pathways (Chang et al., 2008; Chen and Rebay, 2000; Oswald et al., 2002; Rebay et al., 67 2000; Su et al., 2015).”