Notch signaling in the mammalian central nervous system: insights from mouse mutants

By K. Yoon, N. Gaiano. Nature Neuroscience, 2005

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The disintegrin/metalloproteinase ADAM10 is essential for the establishment of the brain cortex (2010, background): “Mouse mutants deficient in genes of the Notch signaling pathway support the view that this pathway plays a critical role in regulating the neural progenitor pool during neocortical development (ArtavanisTsakonas et al., 1999; Hitoshi et al., 2002; Yoon et al., 2004; Mizutani and Saito, 2005; Yoon an”
Notch signalling in vertebrate neural development (2006, background): “Supplementary information S1 (Table) summarizes the phenotypes associated with the various reported knockouts (for a more detailed account of neural phenotypes, see Ref”
Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis. (2006, background): “In light of the critical roles that PTEN and Notch exert during forebrain neurogenesis to maintain neural stem cells or progenitors in a proliferating undifferentiated state (Groszer et al., 2001; Sakamoto et al., 2003; Yoon and Gaiano, 2005), our findings suggest that aggressiveness of glioma growt”