Bace1 modulates myelination in the central and peripheral nervous system

By Xiangyou Hu, C. Hicks, Wanxia He, Philip C. Wong, W. Macklin, B. Trapp, R. Yan. Nature Neuroscience, 2006

618 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/dd191bf88afd858633a773bfe4dd10657f011d91

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. K. Nave
2. R. Mirsky
3. K. Jessen
4. B. Trapp
5. Christian Haass
6. Sangram S. Sisodia
7. D. Holtzman
8. P. Yurchenco

In Molecular Biology

1. Martin Citron
2. Christian Haass
3. K. Nave

In Physiology

1. Philip C. Wong
2. Richard O'Brien
3. Martin Citron
4. Christian Haass
5. Sangram S. Sisodia
6. Huaxi Xu
7. G. Thinakaran
8. C. Kaether

Citations in the corpus

• Trafficking and proteolytic processing of APP. (2012, background): “Whether myelination within the CNS is also under the control of BACE1, as described by Hu et al. (2006), is currently under debate.”
• Amyloid Precursor Protein Processing and Alzheimer’s Disease (2011, background): “BACE1 null mice show altered performance on tests of cognition and emotion (Laird et al. 2005, Savonenko et al. 2008) and have abnormalities of myelination, reflecting alterations in the biology of neuregulin (Hu et al. 2006, Willem et al. 2006).”
• APP processing in Alzheimer's disease (2011, background): “BACE1, as neuregulin 1 is another substrate of BACE1 [85,86].”
• Axon-glial signaling and the glial support of axon function. (2008, background): “NRG1 processing enzymes include the tumor-necrosis factoralpha-converting enzyme for NRG1 type I shedding and the beta-amyloid converting enzyme, which likely activates NRG1 type III (Horiuchi et al. 2005, Hu et al. 2006, Willem et al. 2006).”
• Schwann Cells: Development and Role in Nerve Repair. (2015, background): “In postnatal nerves, neuregulin 1 signaling between axons and Schwann cells is modulated by proteases including Bace1 (b-secretase) and TACE (ADAM17) (Hu et al. 2006; La Marca et al. 2011; Fleck et al. 2012).”
• Alzheimer's disease: strategies for disease modification (2010, background): “BACE1 -knockout mice show hypomyelination of peripheral nerves, because of reduced type III NRG1 cleavage early on postnatally, when BACE1 expression is highest and when nerves are myelinate”