Heart Regeneration in Zebrafish

By K. Poss, Lindsay G Wilson, M. Keating. Science, 2002

1,925 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/dcad3e60c1f392fe0f3b1cdaf1b017160bd1c71c

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In Molecular Biology

Citations in the corpus

Cardiac fibrosis in myocardial infarction—from repair and remodeling to regeneration (2016, background): “Teleostean fish, newts, and embryonic and neonatal rodents are able fully to regenerate an injured area within the myocardium (Becker et al. 1974; Poss et al. 2002; Porrello et al. 2011).”
In vivo drug discovery in the zebrafish (2005, neutral): “Studies of regeneration and behaviour have also been carried out in the adul”
The Oxygen Rich Postnatal Environment Induces Cardiomyocyte Cell Cycle Arrest Through DNA Damage Response (2014, positive): “…of substantial regeneration following injury through cardiomyocyte proliferation (Porrello et al., 2011b, 2013), not unlike urodele amphibians (Becker et al., 1974; Flink, 2002; Oberpriller and Oberpriller, 1974) or teleost fish (González-Rosa et al., 2011; Poss et al., 2002; Wang et al., 2011).”
Unchain my heart: the scientific foundations of cardiac repair. (2005, background): “These include Mps1, encoding a mitotic checkpoint kinase that is induced in the highly proliferative cells of the regeneration blastema (1).”
Pathophysiology of Myocardial Infarction (2015, neutral): “For many years prevailing views in the field of cardiac repair suggested that, in contrast to fish (293) and amphibian organ-”
Production of De Novo Cardiomyocytes: Human Pluripotent Stem Cell Differentiation and Direct Reprogramming (2012, neutral): “In addition, cardiac regeneration without scar tissue has been demonstrated in model organisms, such as zebrafish, after surgical removal of up to 20% of the ventricle (Poss et al., 2002).”
Dedifferentiation, transdifferentiation and reprogramming: three routes to regeneration (2011, background): “Zebrafish can fully regenerate their heart following amputation of up to 20% of the ventricl”
p38 MAP kinase inhibition enables proliferation of adult mammalian cardiomyocytes. (2005, background): “In contrast with mammals, differentiated cells in teleost fish (Poss et al. 2002, 2003) and urodele amphibians (Brockes and Kumar 2002) can dedifferentiate and/or proliferate, enabling regeneration.”
Cardiomyocyte proliferation contributes to heart growth in young humans (2013, background): “In biological models that, unlike adult humans, regenerate myocardium, cardiomyocyte proliferation is important for regeneration as well as postnatal heart growth (10, 11).”
Neuregulin1/ErbB4 signaling induces cardiomyocyte proliferation and repair of heart injury. (2009, neutral): “…to tissue renewal are insulin-producing b cells in the mouse pancreas (Dor et al., 2004), heart muscle cells in regenerating zebrafish hearts (Poss et al., 2002), tracheal cells in Drosophila larvae during metamorphosis (Guha et al., 2008; Weaver and Krasnow, 2008), and Arabidopsis root…”