Neuregulin1/ErbB4 signaling induces cardiomyocyte proliferation and repair of heart injury.

By K. Bersell, S. Arab, B. Haring, B. Kühn. Cell, 2009

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Cardiomyocyte proliferation contributes to heart growth in young humans (2013, background): “3 h in adult ventricular cardiomyocytes (21, 37).”
The Oxygen Rich Postnatal Environment Induces Cardiomyocyte Cell Cycle Arrest Through DNA Damage Response (2014, neutral): “From a mechanistic perspective, several regulators of cardiomyocyte cell cycle have been identified (Agah et al., 1997; Bersell et al., 2009; Chen et al., 2013; Eulalio et al., 2012; Jackson et al., 1990; Liao et al., 2001; Liu et al., 2010; Mahmoud et al., 2013; Porrello et al., 2011a; Reiss et…”
Production of De Novo Cardiomyocytes: Human Pluripotent Stem Cell Differentiation and Direct Reprogramming (2012, positive): “Once within the heart, FHF and SHF cells appear to proliferate in response to endocardial-derived signals, such as neuregulin1 (NRG1), which is driven by NOTCH signaling (Grego-Bessa et al., 2007), and epicardial signals, such as retinoic acid, that function via FGF signaling (Lavine et al., 2005).”
Hippo pathway effector Yap promotes cardiac regeneration (2013, background): “For example, neuregulin signaling has been shown to be necessary and sufficient for postnatal cardiomyocyte proliferation, as has deletion of the Meis1 transcription factor (48, 49).”
Dedifferentiation, transdifferentiation and reprogramming: three routes to regeneration (2011, neutral): “Although this also involves the disassembly of the contractile apparatus, the authors of this stud”