In vivo drug discovery in the zebrafish
By Leonard I. Zon, Randall T. Peterson. Nature reviews. Drug discovery, 2005
1,398 citations recorded by the source corpus.
Subfields: Cell Biology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/de74f79cabf67bc605f1e19bc313573db7dc5c42
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Citations in the corpus
- Force Sensing and Manipulation Strategy in Robot-Assisted Microinjection on Zebrafish Embryos (2011, methodology): “Following the demonstration that it is amenable to large-scale forward genetic screens [1], [2], zebrafish has been increasingly used as a model for the pathogenic mechanisms of human disease and drug discovery [3]–[5].”
- Understanding behavioral and physiological phenotypes of stress and anxiety in zebrafish (2009, methodology): “Contemporary phenotype-based whole-organism drug discovery is bottlenecked by mammalian animal models that are expensive, require ample physical space, large quantities of compounds, and exhibit complex behavioral phenotypes that can be difficult to characterize or quantify [1].”
- Recombinant disintegrin domain of ADAM15 inhibits the proliferation and migration of Bel-7402 cells. (2013, background): “Zebrafish is an important model for studies of evolutionary biology, toxicology and pharmacology and many other fields [26–28].”
- Zebrafish embryos as an alternative to animal experiments--a commentary on the definition of the onset of protected life stages in animal welfare regulations. (2012, background): “usculature, congenital heart defects, anemia, cholesterol proessing, glaucoma, cancer (especially melanoma and leukemia), ddiction, tissue regeneration, hearing disorders, ectodysplasia, pidermolysis bullosa, neural and retinal degeneration as well as nfectious disease [4,7,8].”
- Video-Aided Analysis of Zebrafish Locomotion and Anxiety-Related Behavioral Responses (2011, methodology): “Zebrafish have long been utilized as an experimental animal model for biomedical research, particularly in developmental and genetic studies [12] and drug discovery [7].”