Transcriptional Repression of Atherogenic Inflammation: Modulation by PPARδ

By Chih‐Hao Lee, A. Chawla, Ned Urbiztondo, D. Liao, W. Boisvert, R. Evans. Science, 2003

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Adipocyte-derived Th2 cytokines and myeloid PPARdelta regulate macrophage polarization and insulin sensitivity. (2008, methodology): “Peroxisome proliferator-activated receptor d (PPARd or PPARb), together with PPARg and PPARa, constitutes a subfamily within the nuclear receptor superfamily (Desvergne and Wahli, 1999; Lee et al., 2003b; Reilly and Lee, 2008).”
Integration of metabolism and inflammation by lipid-activated nuclear receptors (2008, neutral): “, and interactions with transcriptional co-repressor”
Therapeutic roles of peroxisome proliferator-activated receptor agonists. (2005, background): “Furthermore, although the precise role of PPAR in the inflammatory process has not been fully elucidated, this receptor may also have anti-inflammatory effects, in particular in macrophages (87).”
PPARs and the complex journey to obesity (2004, background): “3, as you all know how hard it is to build a genetic pathway (Lee et al., 2003a).9 But in this pathway, what we show is that low-density lipoproteins (LDL), the so-called bad cholesterol, becomes even worse when it becomes oxidized.”