Long non-coding RNAs: new players in cell differentiation and development

By Alessandro Fatica, I. Bozzoni. Nature reviews genetics, 2013

2,833 citations recorded by the source corpus.

Subfields: Cancer Research, Endocrinology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/db8aab2a601f4677bbd7f50be9c45c189b0059fa

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In Cancer Research

In Endocrinology

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Citations in the corpus

ChIPBase v2.0: decoding transcriptional regulatory networks of non-coding RNAs and protein-coding genes from ChIP-seq data (2016, background): “The dysregulation of these RNA molecules have been shown to contribute to developmental, physiological and pathological processes (5,7).”
Non-coding RNAs in Development and Disease: Background, Mechanisms, and Therapeutic Approaches. (2016, background): “Developmentally complex organisms harbor an increasing number of lncRNA loci in their genomes and these ncRNAs appear to regulate a number of developmental processes, such as cell differentiation, organogenesis, genomic imprinting, and dosage compensation (73).”
Lnc2Cancer: a manually curated database of experimentally supported lncRNAs associated with various human cancers (2015, background): “Studies have indicated that lncRNAs play critical roles in a wide range of biological processes (6,7).”
The multidimensional mechanisms of long noncoding RNA function (2017, background): “Beyond lncRNA transcription: trans-regulatory activities of lncRNAs A significant body of studies where the lncRNA is specifically depleted without perturbing its gene locus supports the notion that many lncRNAs are active species in regulating gene expression of local or distal genes in different o”
LncRNA-mediated regulation of cell signaling in cancer (2017, background): “…were initially considered as transcriptional noises (Gibb et al 2011), however, it has become increasingly apparent that they may play a critical role in diverse cellular processes from normal development to disease processes (Esteller 2011, Fatica and Bozzoni 2014, Wang et al 2013a, Wilusz 2016).”
MicroRNA (miRNA) in cancer (2015, background): “Emerging evidence has also suggested the involvement of long noncoding RNA (IncRNA) in the development and progression of cancer [10] by exerting their regulatory functions through specific interactions with proteins, including epigenetic modifiers, transcriptional factors/co-activators, and RNP…”