Lnc2Cancer: a manually curated database of experimentally supported lncRNAs associated with various human cancers

By Shangwei Ning, Jizhou Zhang, Peng Wang, Hui Zhi, Jianjian Wang, Yue Liu, Yue Gao, Maoni Guo, M. Yue, Lihua Wang and 1 more. Nucleic Acids Res., 2015

328 citations recorded by the source corpus.

Lnc2Cancer (http://www.bio-bigdata.net/lnc2cancer) is a manually curated database of cancer-associated long non-coding RNAs (lncRNAs) with experimental support that aims to provide a high-quality and integrated resource for exploring lncRNA deregulation in various human cancers. LncRNAs represent a large category of functional RNA molecules that play a significant role in human cancers. A curated collection and summary of deregulated lncRNAs in cancer is essential to thoroughly understand the mechanisms and functions of lncRNAs. Here, we developed the Lnc2Cancer database, which contains 1057 manually curated associations between 531 lncRNAs and 86 human cancers. Each association includes lncRNA and cancer name, the lncRNA expression pattern, experimental techniques, a brief functional description, the original reference and additional annotation information. Lnc2Cancer provides a user-friendly interface to conveniently browse, retrieve and download data. Lnc2Cancer also offers a submission page for researchers to submit newly validated lncRNA-cancer associations. With the rapidly increasing interest in lncRNAs, Lnc2Cancer will significantly improve our understanding of lncRNA deregulation in cancer and has the potential to be a timely and valuable resource.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/a6eeab584f3554f3f1c9a5d4e1c062eaf588bcba

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. Xing Chen
2. Zhuhong You
3. Chenggang Clarence Yan
4. Xu Zhang
5. Qinghua Cui
6. Zhou Huang
7. Zhen Yang
8. Zhenyu Bao

In Molecular Biology

1. Xing Chen
2. Zhuhong You
3. Chenggang Clarence Yan
4. Xu Zhang
5. Qinghua Cui
6. Zhou Huang
7. Zhen Yang
8. Zhenyu Bao

Citations in the corpus

• NONCODEV5: a comprehensive annotation database for long non-coding RNAs (2017, methodology): “Lnc2Cancer is a manually curated database of experimentally supported lncRNAs associated with various human cancers.”
• LncRNADisease 2.0: an updated database of long non-coding RNA-associated diseases (2018, background): “0 with other related database (Table 1), including lncRNAdb (15), Lnc2Cancer (14), EVLncRNAs (29), which are now still available to download.”
• LNCipedia 5: towards a reference set of human long non-coding RNAs (2018, background): “Notable examples of such datasets are Lnc2Cancer (13), LncRNADisease (14), the recently published pan-cancer lncRNA co-expression atlas LncMAP (15) and the Mammal ncRNA Disease Repository (MNDR) that stores 3213 mammalian lncRNAs associated with diseases (16).”
• Long non-coding RNAs and complex diseases: from experimental results to computational models (2016, methodology): “For the prediction, known lncRNA–disease associations in the databases, such as lncRNADisease [106], MNDR [185] and Lnc2Cancer [176], are used as training samples.”