Notch signalling limits angiogenic cell behaviour in developing zebrafish arteries

By Arndt F. Siekmann, Nathan D. Lawson. Nature, 2007

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The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis. (2009, neutral): “…a single Dll4 allele or by interfering with Dll4 or Notch function in mice (Hellstrom et al., 2007; Lobov et al., 2007; Suchting et al., 2007), zebrafish (Leslie et al., 2007; Siekmann and Lawson, 2007), or in experimental tumors (Li et al., 2007; Noguera-Troise et al., 2006; Ridgway et al., 2006).”
Molecular regulation of angiogenesis and lymphangiogenesis (2007, background): “Similarly, endothelial sprouts fail to arrest their angiogenic motile behaviour and branch excessively when Dll4–Notch signalling is compromised in zebrafish embryo”
Molecular control of endothelial cell behaviour during blood vessel morphogenesis (2011, background): “In particular, VEGFR3 is highly expressed in TCs and is required for EC sprouting in mice and zebrafis”
Collective cell migration in morphogenesis, regeneration and cancer (2009, background): “, or of the developing intersegmental vessels in zebrafis”