Nanotechnological strategies for engineering complex tissues

By Tal Dvir, Brian P. Timko, Daniel S. Kohane, Robert Langer. Nature Nanotechnology, 2010

1,295 citations recorded by the source corpus.

Tissue engineering aims at developing functional substitutes for damaged tissues and organs. Before transplantation, cells are generally seeded on biomaterial scaffolds that recapitulate the extracellular matrix and provide cells with information that is important for tissue development. Here we review the nanocomposite nature of the extracellular matrix, describe the design considerations for different tissues and discuss the impact of nanostructures on the properties of scaffolds and their uses in monitoring the behaviour of engineered tissues. We also examine the different nanodevices used to trigger certain processes for tissue development, and offer our view on the principal challenges and prospects of applying nanotechnology in tissue engineering.

Subfields: Biomaterials, Biomedical Engineering

View Paper: https://www.semanticscholar.org/paper/1406d72ab144329ff69600e3c92fa8b12b7e81f4

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In Biomaterials

In Biomedical Engineering

Citations in the corpus

The Extracellular Matrix: Tools and Insights for the “Omics” Era (2015, background): “The ECM provides biophysical and biochemical signals that orchestrate organ formation and function and thus should play a central part in tissue engineering strategies [89].”
Nanotopography-guided tissue engineering and regenerative medicine (2012, background): “, a parallel line is preferred for selective differentiation into neuronal lineage and a dot pattern would be more effective for osteogenic differentiation [47,127,320,321].”
Carbon-Nanotube-Embedded Hydrogel Sheets for Engineering Cardiac Constructs and Bioactuators (2013, positive): “In addition, nanostructure impregnated composite/ hybrid materials were shown to regulate essential cellular functions such as morphogenesis.(2)”
3D cell bioprinting of self-assembling peptide-based hydrogels (2017, background): “ECMs and synthetic constructs [28-31] Although the mechanistic understanding of this association is in its infancy, this level of structure in terms of assembly, control, and communication within the biological environment, are all key for biomaterials development [32-34].”
Emerging trends and new developments in regenerative medicine: a scientometric update (2000 – 2014) (2014, background): “2011 Nanotechnological strategies for engineering complex tissues NAT NANOTECHNOL [68]”