CATs and HATs: the SLC7 family of amino acid transporters

By F. Verrey, E. Closs, C. Wagner, M. Palacín, H. Endou, Y. Kanai. Pflügers Archiv, 2004

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The SLC3 and SLC7 families of amino acid transporters. (2013, background): “The heavy subunit is essential for trafficking of the holotransporter HAT to the plasma membrane, whereas the light subunit catalyzes the transporter function (for reviews see (Palacin and Kanai, 2004; Verrey et al., 2004)).”
The Cystine/Glutamate Antiporter System xc − in Health and Disease: From Molecular Mechanisms to Novel Therapeutic Opportunities (2013, neutral): “System b + is a broadly active amino acid transporter that accepts diamino acids, including cationic amino acids and cystine from the outside and, with lower affinity, also large neutral amino acids and exports neutral amino acids (282).”
Induction of pluripotent stem cells from adult human fibroblasts by defined factors. (2007, methodology): “Mouse Slc7a1 ORF was also amplified, subcloned into pENTR-D-TOPO, and transferred to pLenti6/UbC/V5-DEST (Invitrogen) by the Gateway system.”
CD44 variant regulates redox status in cancer cells by stabilizing the xCT subunit of system xc(-) and thereby promotes tumor growth. (2011, background): “CD98hc is covalently linked to one of several light chains, including LAT1, LAT2, y+LAT1, y+LAT2, and ASC-1 in addition to xCT (Verrey et al., 2004), with the resulting complexes functioning as amino acid transporters at the plasma membrane.”