HIV-1 envelope trimer fusion proteins and their applications

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Induction of Potent Neutralizing Antibody Responses by a Designed Protein Nanoparticle Vaccine for Respiratory Syncytial Virus (2019, background): “, 2015), HIV envelope (Abbott et al., 2018; He et al., 2016; Jardine et al., 2015; McGuire et al., 2016; Sliepen et al., 2015), and Epstein-Barr virus (Kanekiyo et al.”
Presenting native-like trimeric HIV-1 antigens with self-assembling nanoparticles (2016, unknown): “All gp140-FR fusion constructs, including a SOSIP-based design 36 , were transiently co-expressed with furin in HEK293F cells and puriﬁed using GNL followed by SEC on a Superose 6 10/300 GL column.”
Tailored design of protein nanoparticle scaffolds for multivalent presentation of viral glycoprotein antigens (2020, background): “Several reports have utilized non-viral, naturally occurring protein scaffolds, such as self-assembling ferritin (Kanekiyo et al., 2013; Sliepen et al., 2015; Darricarrère et al., 2018), lumazine synthase (Sanders and Moore, 2017; Abbott et al.”
Innate immune recognition of glycans targets HIV nanoparticle immunogens to germinal centers (2018, background): “For example, evidence from preclinical animal models indicates that compared to monomeric antigens, nanoparticulate HIV immunogens more effectively activate low-affinity germline precursor B cells (6–9), promote enhanced follicular helper T cell (Tfh) induction and germinal center (GC) responses (9,”