Medial prefrontal cortex and self-referential mental activity: Relation to a default mode of brain function

By D. Gusnard, E. Akbudak, Gordon L. Shulman, Marcus E. Raichle. Proceedings of the National Academy of Sciences of the United States of America, 2001

4,493 citations recorded by the source corpus.

Subfields: Cognitive Neuroscience

View Paper: https://www.semanticscholar.org/paper/da30e48c527a831c46b9766f6016ccd7ace883fe

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In Cognitive Neuroscience

Citations in the corpus

The default mode network and self-referential processes in depression (2009, background): “Reduction of activity in the DMN during effortful cognitive processing (1, 5) can be interpreted as reflecting the need to attenuate the brain’s self-referential activity as a means of more effectively focusing on a task.”
The Link between Social Cognition and Self-referential Thought in the Medial Prefrontal Cortex (2005, background): “, 2004); or tasks that require reporting on their current emotions (Gusnard et al., 2001).”
The wandering brain: Meta-analysis of functional neuroimaging studies of mind-wandering and related spontaneous thought processes (2015, positive): “…coincided with the parallel discovery that a consistent ‘default mode’ of brain function characterizes the human resting state in functional neuroimaging experiments (Buckner et al., 2008; Gusnard et al., 2001; Raichle, 2010; Raichle et al., 2001; Raichle and Snyder, 2007; Shulman et al., 1997).”
Eigenvector Centrality Mapping for Analyzing Connectivity Patterns in fMRI Data of the Human Brain (2010, background): “On the other hand, posterior cingulate and anterior medial frontal cortex appeared stronger in the second scan - regions that are associated with the ‘‘default mode network’’ [37].”
Social cognitive neuroscience: a review of core processes. (2007, background): “In each of these studies (Gusnard et al. 2001, Johnson et al. 2005, Lane et al. 1997, Ochsner et al. 2004), MPFC was more active during self-reflection than during the control task.”
Functional connectivity of default mode network components: correlation, anticorrelation, and causality (2008, background): “…during resting baseline and decreases in activity during externally oriented cognitive tasks led to the characterization of these regions as belonging to a ‘‘default mode network’’ (DMN) [Esposito et al., 2006; Fransson, 2006; Gusnard et al., 2001a; McKiernan et al., 2003; Raichle et al., 2001].”
The proactive brain: memory for predictions (2009, background): “The default network is believed to subserve the mental processes that take place in the brain when subjects are not engaged in a specific goal-oriented task (Binder et al. 1999; Mazoyer et al. 2001; Raichle et al. 2001).”
Efficiency of Functional Brain Networks and Intellectual Performance (2009, background): “Interestingly, these frontal and parietal regions overlap the oftenreported functional default mode network (Raichle et al., 2001; Greicius et al., 2003; Damoiseaux et al., 2006; Buckner et al., 2008; van den Heuvel et al., 2008c, 2009), a dynamic resting-state network that is suggested to play a…”
Describing Inner Experience? Proponent Meets Skeptic (2011, neutral): “The striking biological phenomenon of suppression of areas involved in introspection during attention demanding tasks that don’t involve social cognition (Goldberg, Harel, & Malach, 2006; Gusnard, 2001), and is best known by reference to the ‘‘default mode network’’ (Raichle et al.”
Neural correlates of individual ratings of emotional salience: a trial-related fMRI study (2004, background): “For instance, MPFC is activated when the subject’s direction of attention shifted internally during personal evaluation of emotional state vs. a nonemotional, impersonal judgment about emotional pictures (Gusnard et al., 2001; Lane et al., 1997a).”
Large-Scale Brain Networks in Cognition: Emerging Principles (2010, background): “The DMN thus collectively comprises an integrated system for autobiographical, selfmonitoring, and social cognitive functions, even though a unique task-based function cannot be assigned to each of its nodes (Spreng et al., 2009).”
Modulation of temporally coherent brain networks estimated using ICA at rest and during cognitive tasks (2008, positive): “It is proposed that the default mode is involved in attending to internal versus external stimuli and is associated with the stream of consciousness, comprising a free flow of thought while the brain is not engaged in other tasks [Gusnard et al., 2001] however there are alternative explanations as w”
Resting-state functional MRI in depression unmasks increased connectivity between networks via the dorsal nexus (2010, neutral): “Among these DMN regions are medial BA8 and medial BA9 regions, which are involved in selfinspection (13) and emotional regulation (14) and demonstrate increased activity in depression (15).”
Age-related Changes in Brain Activity across the Adult Lifespan (2006, background): “Similarly, an increase with age in regions thought to index ‘‘default-mode’’ activity, that is, activity seen when people are in a quiescent state and attending to an internal rather than an external task-based focus ( Gusnard, Akbudak, Shulman, & Raichle, 2001; Raichle et al., 2001), also could si”