An amino-bisphosphonate targets MMP-9-expressing macrophages and angiogenesis to impair cervical carcinogenesis.

By E. Giraudo, M. Inoue, D. Hanahan. Journal of Clinical Investigation, 2004

686 citations recorded by the source corpus.

Subfields: Cancer Research, Hematology, Oncology

View Paper: https://www.semanticscholar.org/paper/d9e112dd38d08502e12f8f5b49b6237b041fd3e8

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. Lisa M. Coussens
2. A. Mantovani
3. J. Pollard
4. P. E. Van den Steen
5. J. Vandooren
6. D. Hanahan
7. G. Opdenakker
8. P. Allavena

In Hematology

1. Lisa M. Coussens
2. J. Vandooren
3. P. E. Van den Steen
4. G. Opdenakker
5. J. Pollard
6. James P. Quigley
7. A. Mantovani
8. E. Deryugina

In Oncology

1. J. Pollard
2. A. Mantovani
3. Lisa M. Coussens
4. D. Hanahan
5. P. Allavena
6. D. DeNardo
7. G. Solinas
8. J. Condeelis

Citations in the corpus

• Clodronate-liposome-mediated depletion of tumour-associated macrophages: a new and highly effective antiangiogenic therapy approach (2006, background): “Recently, the use of bisphosphonates as antiangiogenic agents has been found to suppress solid tumour growth and metastases (Giraudo et al, 2004).”
• Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9): The next decade (2013, methodology): “In this switching process, MMP-9 was shown to act as a proangiogenic factor in several cancer models and Mmp-9 KO mice (Giraudo et al., 2004).”
• CD4+ T Cells Regulate Pulmonary Metastasis of Mammary Carcinomas by Enhancing Protumor Properties of Macrophages (2009, background): “Macrophages are implicated in tumor angiogenesis (a prerequisite for metastasis) by virtue of their capacity to express proangiogenic factors including VEGF and matrix metalloproteinase (MMP)-9 (Giraudo et al., 2004), and by clinical data in human breast cancers demonstrating their presence correlat”
• Tumor‐associated macrophages (TAM) as major players of the cancer‐related inflammation (2009, background): “In estrogen-treated K14HPV16 transgenic mice (cervical carcinogenesis model), TAM production of MMP-9 is crucial for angiogenesis development [89].”
• Tumor-associated macrophages in tumor metastasis: biological roles and clinical therapeutic applications (2019, background): “According to those studies, ZA was able to reverse the polarity of TAMs from M2-like to M1-like by attenuating IL-10, VEGF, and MMP-9 production and recovering iNOS expression [99, 148].”
• Macrophages: obligate partners for tumor cell migration, invasion, and metastasis. (2006, background): “Indeed, in a mouse model for cervical cancer, inhibition of the matrix metalloproteinase MMP9 in macrophages blocked the release of VEGF and thereby inhibited angiogenesis and tumor growth (Giraudo et al., 2004).”
• Macrophages regulate the angiogenic switch in a mouse model of breast cancer. (2006, background): “inhibition of this by bisphosphonate inhibited angiogenesis and reduced tumor incidence and growth (25).”