Short-chain fatty acids in control of body weight and insulin sensitivity

By E. Canfora, J. Jocken, Ellen E. Blaak. Nature Reviews Endocrinology, 2015

1,973 citations recorded by the source corpus.

Subfields: Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/d9cb03215debcfe8fdf2263373ad8f5609412861

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Citations in the corpus

Microbiota metabolite short chain fatty acids, GCPR, and inflammatory bowel diseases (2016, background): “Multiple factors, including diet, specific diversity of gut microbiota and certain amount of commensal bacteria, play a vital role in the production of SCFA [22].”
Exercise Alters Gut Microbiota Composition and Function in Lean and Obese Humans (2017, background): “SCFA can improve skeletal muscle insulin sensitivity (32), reduce inflammation (33), and regulate satiety (34), all of which may contribute to the improvements in body composition observed in this study.”
Gut Microbiota and Short Chain Fatty Acids: Implications in Glucose Homeostasis (2022, background): “The SCFAs effect on GLP-1-mediated increase in insulin secretion can regulate blood glucose concentrations [33].”
Mechanisms of Action of Probiotics. (2019, background): “Consistent with in vitro and in vivo data, SCFAs have been reported to have numerous physiologic, biochemical, and molecular effects in many tissues, including intestine, liver, adipose, muscle, and brain tissues (101).”
Intestinal Short Chain Fatty Acids and their Link with Diet and Human Health (2016, background): “However, in spite of these promising animal data, controlled human intervention studies are still needed before drawing firm conclusions (Canfora et al., 2015).”
The Microbiome-Gut-Brain Axis in Health and Disease. (2017, background): “SCFAs are also involved in energy balance and metabolism, and can modulate adipose tissue, liver tissue and skeletal muscle and function 12 .”
Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics (2017, positive): “Shortchain fatty acids (SCFAs), such as acetate, propionate and butyrate, and some other compounds, are recognized as having mechanistic links to health outcomes 28,29 .”
Short chain fatty acids in human gut and metabolic health. (2020, positive): “…of obesity and related diseases such as type 2 diabetes mellitus (T2DM) by affecting body weight control through effects on energy intake and energy expenditure, as well as insulin sensitivity and systemic low-grade (Canfora et al. , 2015; Chambers et al. , 2018c; Rios-Covian et al. , 2016).”
The role of short-chain fatty acids in the interplay between gut microbiota and diet in cardio-metabolic health (2021, background): “Several studies have suggested that SCFAs can improve glucose homeostasis in vivo by controlling blood glucose levels and increasing glucose uptake mediated by FFAR2 and FFAR3 activation.(111,112,134) Although the mechanisms are not completely clear, such effects might happen directly via an AMPacti”
Gut instincts: microbiota as a key regulator of brain development, ageing and neurodegeneration (2017, background): “…a significant role in modulating brain function and behaviour and that the microbiota–gut–brain axis is poised as a bidirectional communication pathway enabling gut microbes to communicate with the brain, and the brain with the gut (Rhee et al. 2009; Canfora et al. 2015; Foster et al. 2016).”
SCFA: mechanisms and functional importance in the gut (2020, background): “As discussed in this review, the gut microbial metabolites SCFA are well known to exert a wide beneficial impact to the host((167,168)).”