IL-17 Production Is Dominated by γδ T Cells rather than CD4 T Cells during Mycobacterium tuberculosis Infection1

By E. Lockhart, A. Green, J. Flynn. Journal of Immunology, 2006

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Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity. (2009, background): “…that unconventional T cells, especially NKT cells, express the IL-23R and secrete IL-17 during infection or inflammation or when activated in vitro with anti-CD3 and IL-23 or with the synthetic ligand a-galactosylceramide (Lockhart et al., 2006; Rachitskaya et al., 2008; Shibata et al., 2007).”
The immune response in tuberculosis. (2013, background): “During mycobacterial infections, IL-17 can also be produced by γδ T cells and a non-CD4+ CD8+ population (284).”
Interleukin-17-producing gammadelta T cells selectively expand in response to pathogen products and environmental signals. (2009, background): “For instance, in Mycobacterium tuberculosis (Mtb) infection, gd T cells isolated from the lung are the main primary source of IL-17 (Lockhart et al., 2006; Umemura et al., 2007).”
The Microbiome in Infectious Disease and Inflammation (2012, neutral): “During Mycobacterium tuberculosis infection, γδ T cells are the main source of IL-17 in the lung (184).”