A Gene Network Regulating Lysosomal Biogenesis and Function

By Marco Sardiello, M. Palmieri, Alberto di Ronza, Diego L. Medina, M. Valenza, V. A. Gennarino, Chiara Di Malta, Francesca Donaudy, V. Embrione, R. Polishchuk and 4 more. Science, 2009

2,364 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/92bd5576a9cfcb227b7683d2c9e9958bfdcf6f4a

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Citations in the corpus

The lysosome: from waste bag to potential therapeutic target. (2013, background): “Interestingly, the TFEB pathway is activated under lysosomal storage conditions and might be responsible for the increased size of the lysosomal compartment that is present in these disorders (Sardiello et al., 2009).”
Molecular mechanisms and potential therapeutical targets in Huntington's disease. (2010, background): “Molecular Mechanisms and Potential Therapeutical Targets in Huntington’s Disease CHIARA ZUCCATO, MARTA VALENZA, AND ELENA CATTANEO Department of Pharmacological Sciences and Centre for Stem Cell Research, Università degli Studi di Milano, Milan, Italy I. Introduction 906 II.”
TFEB-mediated autophagy rescues midbrain dopamine neurons from α-synuclein toxicity (2013, methodology): “Expression of miR-128, identified as a negative regulator of TFEB (35), caused a significant reduction in the expression of both TFEB and its ALP-related targets and resulted in amarkedpotentiation ofα-syn toxicity.”
Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways. (2011, methodology): “Briefly, HeLa TFEB-FLAG stable transfectants (17) were grown up to 50% confluence and crosslinked in 1% formaldehyde for 10 min and lysed on ice for 20 min in ChIP-Lysis buffer (50 mM Tris–HCl, pH 7.”
Deciphering the Molecular Signals of PINK1/Parkin Mitophagy. (2016, background): “Lysosome biogenesis is dynamically regulated during starvation-induced autophagy by cytosolto-nucleus relocalization of transcription factor EB (TFEB) [72].”
TFEB at a glance (2016, background): “In resting cells, under nutrient-rich conditions, TFEB is largely cytosolic and inactive (Sardiello et al., 2009; Settembre et al., 2011).”
Lysosomal membrane permeabilization and cell death (2018, background): “This phenomenon is probably related to TFEB activation; lysosomal enlargement has been shown to induce activation of TFEB as a compensatory mechanism to generate more lysosomes.(16,35)”
Phosphatidylinositol-5-phosphate 4-kinases regulate cellular lipid metabolism by facilitating autophagy (2018, background): “In normal or nutrient rich conditions, TFEB is localized to the cytoplasm (Sardiello et al., 2009).”
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (2012, neutral): “some and autophagosome biogenesis was identified using a systems-biology approach.(625,635,636) The basic helix-loophelix transcription factor TFEB acts as a master gene of the”
A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB (2012, background): “A major player in the regulation of lysosomal biogenesis is the basic Helix-Loop-Helix (bHLH) leucine zipper transcription factor, TFEB (Sardiello et al , 2009).”