Immunomodulatory properties of mesenchymal stromal cells.

By A. Nauta, W. Fibbe. Blood, 2007

1,784 citations recorded by the source corpus.

Subfields: Genetics, Rehabilitation, Surgery

View Paper: https://www.semanticscholar.org/paper/d97e09ba56e20500f2e5bb5b843a5ba09a8ad813

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. Jaehyup Kim
2. Christopher S. Chen
3. A. Keating
4. Aline M. Betancourt
5. Ruth S. Waterman
6. Suzanne L. Tomchuck
7. J. Karp
8. P. Hematti

In Rehabilitation

1. A. Keating
2. J. Karp

In Surgery

1. Jaehyup Kim
2. A. Keating
3. J. Karp
4. P. Hematti

Citations in the corpus

• Control of stem cell fate by physical interactions with the extracellular matrix (2009, background): “Furthermore, the decreased immunogenicity (Nauta and Fibbe, 2007) and potentially ‘‘immunosuppressive’’ properties that have been described”
• Harnessing the Mesenchymal Stem Cell Secretome for the Treatment of Cardiovascular Disease (2012, background): “MSCs are known to be the source of multiple immunomodulatory agents plus trophic factors involved in repair and regenerative processes (Nauta and Fibbe, 2007; van Poll et al., 2008).”
• Mesenchymal stromal cells: new directions. (2012, background): “This topic has been covered extensively in several reviews (Nauta and Fibbe, 2007; Le Blanc and Ringdén, 2007; Uccelli et al., 2008; Tolar et al., 2010; Chen et al., 2011, among others), and I will therefore focus on drawing attention to a few key issues.”
• A New Mesenchymal Stem Cell (MSC) Paradigm: Polarization into a Pro-Inflammatory MSC1 or an Immunosuppressive MSC2 Phenotype (2010, background): “Toll-like receptors recognize “danger” signals and their activation leads to profound cellular and systemic responses that mobilize innate and adaptive host immune cells [16]– [20].”
• Mesenchymal stem cell-educated macrophages: a novel type of alternatively activated macrophages (2009, background): “Although the interaction of MSCs with T-lymphocytes, B-lymphocytes, natural killer cells and dendritic cells have been investigated in detail [20], there is very little known about the interaction of MSCs with cells of monocytic lineages, specifically macrophages.”
• Mesenchymal stem cell homing: the devil is in the details. (2009, neutral): “…and their potential to differentiate into tissue-specific cell types (Sasaki et al., 2008; Toma et al., 2002) with trophic activity (Zhang et al., 2007), to promote vascularization (Martens et al., 2006), and to promote potent immunosuppressive effects (reviewed in Nauta and Fibbe, 2007).”