HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment
By Cesar A. Corzo, T. Condamine, Lily Lu, M. Cotter, Je-in Youn, P. Cheng, Hyun-Il Cho, E. Celis, D. Quiceno, T. Padhya and 3 more. Journal of Experimental Medicine, 2010
1,073 citations recorded by the source corpus.
The hypoxic environment of tumors dictates the phenotype of local myeloid-derived suppressor cells (MDSCs) via HIF-1a expression; hypoxia converts splenic MDSCs from specific into nonspecific suppressors.
Subfields: Cancer Research, Immunology
View Paper: https://www.semanticscholar.org/paper/77cf3cf3976e026979d2b7acf9b04119740a45f1
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In Cancer Research
- Rakesh K. Jain
- Dai Fukumura
- John D. Martin
- Lance L. Munn
- D. Duda
- V. Bronte
- S. Kierans
- Cormac T. Taylor
In Immunology
Citations in the corpus
- Chemokine nitration prevents intratumoral infiltration of antigen-specific T cells (2011, background): “Recently, hypoxia-inducible factor 1 was shown to drive the program leading to ARG1 and NOS2 up-regulation in mouse tumor-associated macrophages (Corzo et al., 2010; Doedens et al., 2010).”
- Vascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapy (2012, background): “In breast cancer, the abundant TAMs and MDSCs suppress anticancer immunity and promote tumor progression (5, 8, 14, 16).”
- Regulation of glycolysis by the hypoxia‐inducible factor (HIF): implications for cellular physiology (2020, background): “First, hypoxia within the tumour microenvironment can accelerate the rate of glycolysis in MDSCs via HIF-1α, to promote proliferation of these cells and potentiate their immunosuppressive effects (Corzo et al. 2010).”