Leptin regulation of neuroendocrine systems.

By R. Ahima, Clifford B. Saper, J. Flier, J. Elmquist. Frontiers in neuroendocrinology (Print), 2000

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Brief Communication: Sleep Curtailment in Healthy Young Men Is Associated with Decreased Leptin Levels, Elevated Ghrelin Levels, and Increased Hunger and Appetite (2004, background): “In addition, because age and sex may affect neuroendocrine regulation of appetite ( 3 , 5), our findings may not readily apply to women and older adults.”
Physiological role of adipose tissue: white adipose tissue as an endocrine and secretory organ (2001, positive): “Leptin interacts with several central neuroendocrine systems, including neuropeptide Y (Stephens et al. 1995; Ahima et al. 2000), leading to the inhibition of food intake (Campfield et al.”
Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis. (2006, positive): “Establishing the Functional Neuroanatomy of Body-Weight Control In recent years, a number of proteins have been identified, such as leptin, the leptin receptor (LEPR), and the melancortin-4 receptor, that play key roles in the central regulation of energy homeostasis ( Ahima et al., 2000; Cone, 200”
Mouse models in non‐alcoholic fatty liver disease and steatohepatitis research (2006, background): “This drives a desire to seek food and suppresses the thyroid, growth hormone, adrenal and reproductive endocrine axes (Ahima et al. 2000).”