Shh and Gli3 are dispensable for limb skeleton formation but regulate digit number and identity

By Y. Litingtung, R. Dahn, Yina Li, J. Fallon, C. Chiang. Nature, 2002

608 citations recorded by the source corpus.

Subfields: Developmental Biology, Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/d8ee6ebe472ec6ea2ad6785a0d298c5f1d1a6c1b

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

In Molecular Biology

Citations in the corpus

The graded response to Sonic Hedgehog depends on cilia architecture. (2007, background): “Proteolytically processed forms of Gli proteins (Gli-repressor) can inhibit transcription of target genes in the absence of ligand, and full-length Gli proteins can be modified in the presence of Hh ligands (Gli-activator) to promote target gene transcription (Dai et al., 1999; Litingtung et al., 20”
Genome-wide RNA Tomography in the zebrafish embryo. (2014, background): “Tomo-seq traces and expression changes in Gli3 / limbs are in full agreement with published whole-mount in situ data (Litingtung et al., 2002).”
Gli proteins in development and disease. (2011, background): “Simultaneous inactivation of Shh and Gli3 results in severe polydactyly and loss of AP identities, similar to the defects observed in Gli3-null limbs (Litingtung et al. 2002, te Welscher et al. 2002b), which indicates that one of the main functions of Shh is to counteract Gli3R.”
Hedgehog Signaling in the Subventricular Zone Is Required for Both the Maintenance of Stem Cells and the Migration of Newborn Neurons (2007, background): “In addition, in many contexts (Litingtung et al., 2002), most notably in dorsoventral patterning of the telencephalon and dorsoventral midbrain (Rallu et al., 2002; Blaess et al., 2006), Hh functions primarily to attenuate the activity of the Gli3 repressor, rather than to activate Hh signaling…”
Hedgehog: functions and mechanisms. (2008, background): “GLI3, in turn, functions primarily as a repressor (B. Wang et al. 2000; Litingtung et al. 2002), and its loss or mutation leads to limb malformations in mice and humans (Vortkamp et al.”
Gli2 and Gli3 Localize to Cilia and Require the Intraflagellar Transport Protein Polaris for Processing and Function (2005, background): “alone, leading to the hypothesis that a pentadactyl restraint is imposed on the limb by Shh counteraction of Gli3 repressor activity [13,14].”