miRTarBase update 2014: an information resource for experimentally validated miRNA-target interactions

By Sheng-Da Hsu, Y. Tseng, S. Shrestha, Yu-Ling Lin, Anas Khaleel, Chih-Hung Chou, Chao-Fang Chu, Hsi-Yuan Huang, Ching-Min Lin, S. Ho and 8 more. Nucleic Acids Res., 2013

705 citations recorded by the source corpus.

MicroRNAs (miRNAs) are small non-coding RNA molecules capable of negatively regulating gene expression to control many cellular mechanisms. The miRTarBase database (http://mirtarbase.mbc.nctu.edu.tw/) provides the most current and comprehensive information of experimentally validated miRNA-target interactions. The database was launched in 2010 with data sources for >100 published studies in the identification of miRNA targets, molecular networks of miRNA targets and systems biology, and the current release (2013, version 4) includes significant expansions and enhancements over the initial release (2010, version 1). This article reports the current status of and recent improvements to the database, including (i) a 14-fold increase to miRNA-target interaction entries, (ii) a miRNA-target network, (iii) expression profile of miRNA and its target gene, (iv) miRNA target-associated diseases and (v) additional utilities including an upgrade reminder and an error reporting/user feedback system.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/bf4b4c751171aee89108efa41cfae10cb7453adf

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In Cancer Research

  1. Maria D. Paraskevopoulou
  2. Theodore Dalamagas
  3. Ioannis S. Vlachos
  4. Thanasis Vergoulis
  5. G. Georgakilas
  6. Artemis G. Hatzigeorgiou

In Molecular Biology

  1. Maria D. Paraskevopoulou
  2. Theodore Dalamagas
  3. Ioannis S. Vlachos
  4. Thanasis Vergoulis
  5. G. Georgakilas
  6. Artemis G. Hatzigeorgiou
  7. Dimitra Karagkouni

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