SUMO-modified PCNA recruits Srs2 to prevent recombination during S phase

By B. Pfander, George‐Lucian Moldovan, Meik Sacher, C. Hoege, S. Jentsch. Nature, 2005

649 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/d85b5b1ff8f5936ac6910df13351a625fe09493d

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Citations in the corpus

Homologous recombination and its regulation (2012, background): “Additionally, Srs2 is SUMOylated near the C-terminus of the protein [(147) and our unpublished data], a region that interacts with both SUMO and PCNA and is required to prevent unscheduled recombination events at replication forks (149,150).”
Maintaining genome stability at the replication fork (2010, background): “cerevisiae PCNA is known to mediate the recruitment of Srs2 to sites of damage and favour certain recombination events ther”
A novel function of DNA polymerase ζ regulated by PCNA (2006, background): “Sumoylation has been suggested to inhibit homologous recombination in the S phase of the cell cycle (Haracska et al, 2004; Papouli et al, 2005; Pfander et al, 2005 ).”
Regulation of DNA repair throughout the cell cycle (2008, background): “SUMO modifications modulate DNA repair Increasing evidence suggests that sumoylation ( Box 3 ) of specific targets has a role in protecting genome integrity and in modulating DNA repai”
The SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition (2010, background): “In yeast, SUMO modification of PCNA at Lys164 and Lys127 during S phase recruits the anti-recombinogenic ATP-dependent DNA helicase Srs2 in a manner that is dependent on a SIM located at its C terminu”
Regulation of homologous recombination in eukaryotes (2010, background): “Alternatively, K164 (and K127) can be sumoylated by Ubc9, which leads to recruitment of the Srs2 antirecombinase through its SUMO binding motif (122, 124).”
Sumoylation: a regulatory protein modification in health and disease. (2013, background): “Typical examples for SIM-dependent events are the recruitment of the helicase Srs2 to the sumoylated DNA sliding clamp PCNA in S phase (121, 122), and transcriptional repression via recruitment of Daxx to sumoylated transcription factors (182).”
PCNA, the maestro of the replication fork. (2007, positive): “However, genetic studies indicated that PCNA SUMOylation is inhibitory for DNA repair if the RAD6 bypass pathway is not functional (Hoege et al., 2002; Pfander et al., 2005).”
Reading protein modifications with interaction domains (2006, background): “For example, the sumoylation ? as opposed to the ubiquitylation ? of PCNA at Lys164 promotes high fidelity replication by recruiting a helicase (Srs2) that contains a SIM to replication forks, thereby preventing inappropriate recombinational repai”