PCNA, the maestro of the replication fork.

By George‐Lucian Moldovan, B. Pfander, S. Jentsch. Cell, 2007

1,860 citations recorded by the source corpus.

Inheritance requires genome duplication, reproduction of chromatin and its epigenetic information, mechanisms to ensure genome integrity, and faithful transmission of the information to progeny. Proliferating cell nuclear antigen (PCNA)-a cofactor of DNA polymerases that encircles DNA-orchestrates several of these functions by recruiting crucial players to the replication fork. Remarkably, many factors that are involved in replication-linked processes interact with a particular face of PCNA and through the same interaction domain, indicating that these interactions do not occur simultaneously during replication. Switching of PCNA partners may be triggered by affinity-driven competition, phosphorylation, proteolysis, and modification of PCNA by ubiquitin and SUMO.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/aceff42802e9b1946db31658d2876cf1b51b58d8

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Citations in the corpus

Histone lysine methyltransferase SETD8 promotes carcinogenesis by deregulating PCNA expression. (2012, methodology): “293T cells were transfected with FLAG-PCNA (WT) or FLAG-PCNA (K248A) andHA-SETD8 (1-352) expression vectors.”
The SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition (2010, background): “For PCNA, ubiquitylation on Lys164 does not result in proteasomal degradation, but rather initiates post-replication repai”
The DNA Damage Response: Making it safe to play with knives (2010, background): “PCNA accumulates rapidly at sites of DNA damage, where it recruits DDR factors containing PCNA interaction motifs (Moldovan et al., 2007).”
p21 in cancer: intricate networks and multiple activities (2009, background): “Through binding to PCNA, p21 competes for PCNA binding with DNA polymerase-δ and several other proteins involved in DNA synthesis, thus directly inhibiting DNA synthesi”
A model for transmission of the H3K27me3 epigenetic mark (2008, background): “1a–c ) and therefore at sites of ongoing DNA replicatio”
The DNA damage response: ten years after. (2007, background): “The ssDNA-RPA complex then plays two critical roles: it recruits the ATR protein through its regulatory subunit ATRIP (Zou and Elledge, 2003), and it recruits and activates the Rad17 clamp loader which then loads the PCNA-related 911 (Rad9Rad1-Hus1) complex onto DNA (Yang and Zou, 2006).”
Murine Features of Neurogenesis in the Human Hippocampus across the Lifespan from 0 to 100 Years (2010, background): “PCNA is critically involved in DNA replication [64] and has thus been established and is widely used as a proliferation marker.”
Epigenetic inheritance during the cell cycle (2009, background): “DNA polymerases are assisted by the DNA processivity factor proliferating cell nuclear antigen ( PCNA”
Chromatin Structure and the Inheritance of Epigenetic Information (2010, background): “Finally, the replicative DNA polymerase and auxiliary proteins — including the clamp loader (replication factor C (RFC)), the clamp (proliferating cell nuclear antigen ( PCNA )) and the single-strand DNA-binding protein replication protein A (RPA”
How the fanconi anemia pathway guards the genome. (2009, background): “Finally, it is attractive to imagine that modified FANCD2-I can enhance the activity of repair enzymes, perhaps by localizing them to their substrate (Figure 4c), in analogy to PCNA ubiquitination-dependent recruitment of TLS polymerases (63, 96).”
Most Random Gene Expression Signatures Are Significantly Associated with Breast Cancer Outcome (2011, background): “The proliferating cell nuclear antigen, PCNA, is a ring-shaped protein that encircles DNA and regulates several processes leading to DNA replication [53].”
Proliferating cell nuclear antigen (PCNA): a key factor in DNA replication and cell cycle regulation. (2011, neutral): “Key words: Proliferating cell nuclear antigen, PCNA, cyclin, DNA replication, DNA repair, cell cycle.”