Regulation of mitochondrial dynamics in acute kidney injury in cell culture and rodent models.

By C. Brooks, Qingqing Wei, Sung-Gyu Cho, Z. Dong. Journal of Clinical Investigation, 2009

724 citations recorded by the source corpus.

Subfields: Molecular Biology, Nephrology, Surgery

View Paper: https://www.semanticscholar.org/paper/d8390064c908ef210af6a83af7b9065cbb0d0a54

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The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. A. Suomalainen
2. J. Forbes
3. M. Cooper
4. J. Nunnari
5. S. Borkan
6. Chuang-Rung Chang
7. A. Havasi
8. D. C. Chan

In Surgery

1. J. Forbes
2. M. Cooper

Citations in the corpus

• Mechanisms of diabetic complications. (2013, background): “This suggests that although mitochondrial abnormalities may be early manifestations of the disease, the ultimate loss of ATP generation is likely to contribute to end-organ decline and cell death in the later stages of disease progression (64, 578).”
• Mitochondrial Fission Contributes to Mitochondrial Dysfunction and Insulin Resistance in Skeletal Muscle (2011, background): “For example, mitochondrial fission occurs in the kidneys and heart after acute ischemia/reperfusion injury in mice, and prevention of this process is beneficial (5, 32).”
• Mitochondria: In Sickness and in Health (2012, background): “…and drug toxicities are also associatedwith increasedmitochondrial fragmentation in cultured cells models and in animal models of myocardial infarction and drug induced renal toxicity, inhibition of mitochondrial division has shown therapeutic promise (Brooks et al., 2009; Ong et al., 2010).”
• Apoptosis and acute kidney injury. (2011, background): “In fact, fragmentation was detected in murine proximal tubular mitochondria after renal ischemia and cisplatin nephrotoxicity.(67) It now appears that mitochondrial fragmentation is a relatively early event that precedes outer mitochondrial membrane disruption, Bax activation, and apoptosis.”
• Pathophysiology of Acute Kidney Injury (2012, neutral): “Mitochondrial fission is more pronounced following ATP depletion in cultured proximal tubule cells and this change is thought to contribute to outer membrane permeabilizataion and consequent apoptosis (76).”