Vernalization requires epigenetic silencing of FLC by histone methylation

By R. Bastow, J. Mylne, C. Lister, Z. Lippman, R. Martienssen, C. Dean. Nature, 2004

947 citations recorded by the source corpus.

Subfields: Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/d8331e03e0e246e040ac49495b0330c836d3c621

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Citations in the corpus

Epigenetics in plant tissue culture (2011, background): “In Arabidopsis, vernalization involves the silencing of a group of flowering repressor genes, including Flowering Locus C (FLC; Bastow et al. 2004; Roudier et al. 2009).”
Seasonal and developmental timing of flowering. (2010, methodology): “As discussed above, H3K9 methylation is an additional repressive chromatin mark that accumulates at FLC as a result of vernalization-mediated repression, and appears to be involved in maintenance (Bastow et al., 2004; Sung and Amasino, 2004; Sung et al., 2006; Greb et al., 2007).”
Inherited epigenetic variation — revisiting soft inheritance (2006, background): “For example, prolonged cold-temperature treatments in plants can lead to both chromati”
Arabidopsis TFL2/LHP1 Specifically Associates with Genes Marked by Trimethylation of Histone H3 Lysine 27 (2007, positive): “VRN2 is critical for the maintenance of transcriptional repression of FLC after vernalization [49] and leads to an enrichment of H3K27me3 over FLC [17,44].”
Multiple Pathways in the Decision to Flower: Enabling, Promoting, and Resetting (2004, background): “…expression was unaffected in these lines until the plants had been vernalized, demonstrating that VRN1 requires vernalization-specific factors to target FLC. Methylation of the Lys-27 residue on histone H3 by the VRN2 complex may be the vernalization-specific process required (Bastow et al., 2004).”
Large deletions within the first intron in VRN-1 are associated with spring growth habit in barley and wheat (2005, background): “It was recently demonstrated that vernaliza- tion requires epigenetic silencing of FLC by histone methylation and acetylation in specific regions of intron 1 (He et al. 2003; Bastow et al. 2004).”
Seasonal shifts in dormancy status, carbohydrate metabolism, and related gene expression in crown buds of leafy spurge (2005, background): “Induction of flower competency by cold is known to involve chromatin remodelling of specific genes involved in flower development such as FLOWERING LOCUS C (Bastow et al. 2004; Sung & Amasino 2004; He & Amasino 2005).”
Photoperiodic flowering of Arabidopsis: integrating genetic and physiological approaches to characterization of the floral stimulus (2005, background): “Consistent with vernalization acting in the meristem, FLC is expressed specifically in the shoot and root meristems in young seedlings, although in older plants it is also expressed in expanded leaves (Michaels & Amasino 2000; Sheldon et al. 2002; Noh & Amasino 2003; Bastow et al. 2004).”
The timing of developmental transitions in plants. (2006, background): “…PcG complex PRC2 is thought to be responsible for histone H3 lysine 27 and possibly H3 lysine 9 methylation (Czermin et al., 2002; Müller et al., 2002), and FLC chromatin was found to accumulate these histone marks after vernalization (Bastow et al., 2004; Sung and Amasino, 2004).”
The transcription factor FLC confers a flowering response to vernalization by repressing meristem competence and systemic signaling in Arabidopsis. (2006, background): “FLC is expressed widely, including in the meristem and leaves (Sheldon et al. 2002; Noh and Amasino 2003; Bastow et al. 2004).”