Molecular views of recombination proteins and their control

By S. West. Nature reviews. Molecular cell biology, 2003

1,019 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/d7e1d590524b942124349a5acf073f3bd09faa06

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. J. Bartek
2. J. Lukas
3. S. Boulton
4. P. Jeggo
5. C. Lord
6. C. Lukas
7. Alan Ashworth
8. R. Brough

In Oncology

1. J. Bartek
2. J. Lukas
3. P. Jeggo
4. C. Lord
5. C. Lukas
6. S. Boulton
7. Alan Ashworth
8. R. Brough

Citations in the corpus

• RAD51 and Breast Cancer Susceptibility: No Evidence for Rare Variant Association in the Breast Cancer Family Registry Study (2012, background): “4) is the central protein of homologous recombination, playing the critical role of catalyzing the strand transfer between a broken sequence and its undamaged homologue in order to re-synthesize the damaged region [16].”
• Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors (2009, positive): “Extending this observation, we demonstrated that PTEN mutant tumour cells also had a reduced capacity to form nuclear RAD51 foci in response to DNA damage, a surrogate marker of HR activity (West, 2003) (Fig 1B, Figs S1B and S2 of Supporting Information).”
• Concerted Loading of Mcm2-7 Double Hexamers Around DNA during DNA Replication Origin Licensing (2009, background): “This is analogous to the bacterial RuvAB Holliday junction branch migrating enzyme in which two RuvB hexamers pump double-stranded DNA through a tetramer of RuvA, which coordinates the separation and reannealing of strands (West, 2003).”
• The role of double-strand break repair — insights from human genetics (2006, methodology): “DNA synthesis using the sister strand as a template is followed by branch migration and subsequent resolution of the heteroduplex (see Ref”
• The roles of BRCA1 and BRCA2 and associated proteins in the maintenance of genomic stability (2006, background): “Other proteins implicated in assisting this process include RAD54, the RAD51 paralogues and BRCA2 (van Gent et al., 2001; West, 2003).”
• Alternative-NHEJ Is a Mechanistically Distinct Pathway of Mammalian Chromosome Break Repair (2008, background): “RAD52 can function in vitro to directly promote homologous strand annealing, and also to mediate RAD51 function during strand exchange [28].”
• RIF1 Is Essential for 53BP1-Dependent Nonhomologous End Joining and Suppression of DNA Double-Strand Break Resection (2013, background): “In contrast, HR is a largely error-free mechanism of DSB repair that is primarily active in S and G2 cell cycle phases, which requires an intact homologous duplex sequence as a repair template (West, 2003).”
• Regulation of homologous recombination in eukaryotes (2010, background): “Finally, in postsynapsis, the three subpathways of HR are distinguished (Figure 1), each with specific enzymatic requirements that have been only partially defined (69, 91, 129, 161).”