Rapid Rewiring of Arcuate Nucleus Feeding Circuits by Leptin

By Shirly Pinto, A. G. Roseberry, Hongyan Liu, S. Diano, M. Shanabrough, Xiaoli Cai, J. Friedman, T. Horvath. Science, 2004

1,017 citations recorded by the source corpus.

Subfields: Cognitive Neuroscience, Endocrine and Autonomic Systems, Nutrition and Dietetics

View Paper: https://www.semanticscholar.org/paper/d7a8609782c9caee77eb9194c49ecc2ea733d66e

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cognitive Neuroscience

1. S. O’Rahilly
2. R. Hen
3. Elizabeth M. C. Hillman
4. A. Pol
5. Erika Gyengesi
6. Laszlo Zaborszky

In Endocrine and Autonomic Systems

1. S. O’Rahilly
2. Elizabeth M. C. Hillman
3. K. Murphy
4. Matthias Tschöp
5. Stephen R. Bloom
6. Roger Cone

In Nutrition and Dietetics

1. S. O’Rahilly
2. K. Murphy
3. Matthias Tschöp
4. Stephen R. Bloom
5. G. Karsenty
6. Roger Cone

Citations in the corpus

• Genetics of obesity in humans. (2006, background): “In addition, synaptic plasticity in the mature rodent brain has been identified as a component of the neuronal regulation of energy homeostasis because leptin has been shown to acutely modulate excitatory and inhibitory synaptic inputs at the level of first-order arcuate neurones (60).”
• Brain foods: the effects of nutrients on brain function (2008, neutral): “Ghrelin also promotes rapid reorganization of synaptic terminals in the hypothalamu”
• Leptin receptor signaling in midbrain dopamine neurons regulates feeding. (2006, neutral): “ghrelin treatment ( Pinto et al., 2004 ) would suggest a potential mode of regulation that may be relevant within mesolimbic and mesocortical circuits.”
• Leptin and Obesity: Role and Clinical Implication (2021, methodology): “Among ob/ob mice and wild-type mice are different synapses extended on NPY/AgRP and POMC neurons (40).”
• Leptin Action on GABAergic Neurons Prevents Obesity and Reduces Inhibitory Tone to POMC Neurons (2011, neutral): “Perhaps the key leptin-responsive target genes do not encode neuropeptides, but instead, proteins involved in modulating GABA release, or possibly proteins that regulate plasticity of GABAergic synapses (Pinto et al., 2004).”
• Leptin regulation of bone mass, appetite and energy expenditure relies on its ability to inhibit serotonin synthesis in the brainstem (2009, positive): “The lower POMC perikaryal diameter of ob/ob mice is associated with a 50% decrease in the number of perikaryal synapse density of POMC neurons (Pinto et al., 2004).”
• The Basal Forebrain Cholinergic Projection System in Mice Neuron Types in the Basal Forebrain - Chapter 28 The Mouse Nervous System (2012, background): “There is a substantial amount of data that has been collected that focuses on the anatomy and function of NPY neurons in the mouse hypothalamus and their role in food intake regulation, maintenance of energy homeostasis and obesity (Pinto et al., 2004).”
• The Hormonal Control of Food Intake (2007, neutral): “By studying the electrophysiological activity in neurons from ob/ob mice, it was shown that leptin deficiency markedly changes synaptic inputs to arcuate neurons, increasing excitatory inputs on NPY/AgRP neurons but decreasing excitatory inputs to POMC neurons (Pinto et al., 2004).”
• Ghrelin controls hippocampal spine synapse density and memory performance (2006, background): “In addition to the acute electrophysiological effects of ghrelin on these neurons, peripheral ghrelin administration has also been shown to rapidly reorganize the synaptic inputs of POMC neuron”
• Optical brain imaging in vivo: techniques and applications from animal to man. (2007, background): “Figure 4 d right shows similar data acquired in a transgenic mouse, engineered such that only certain neurons in the brain express green fluorescent protein.(130,131) Capillaries perfused with Texas dextran red can be seen to be weaving amidst the webs of dendrites.”
• Physiology of leptin: energy homeostasis, neuroendocrine function and metabolism. (2015, background): “Leptin administration in ob/ob mice rapidly normalizes synaptic inputs to POMC and AgRP neurons to levels seen in wild-type mice [47].”
• Gut hormones and the regulation of energy homeostasis (2006, background): “Peptide YY and the Y2 agonist PYY-(13-36) inhibit neurons of the dorsal motor nucleus of the vagus.”