PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect

By S. Tunaru, J. Kero, Annette Schaub, C. Wufka, A. Blaukat, K. Pfeffer, S. Offermanns. Nature Medicine, 2003

792 citations recorded by the source corpus.

Subfields: Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/d76983c0cbb3ad282aad7744dc82140eabd2396f

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In Molecular Biology

1. Johan Auwerx
2. S. Coughlin
3. C. Cantó
4. S. Ghosh
5. Isaac T. Sato
6. P. Crawford
7. Patrycja Puchalska
8. J. Regard

In Physiology

1. Johan Auwerx
2. Keir J. Menzies
3. C. Cantó
4. S. Ghosh
5. P. Crawford
6. Patrycja Puchalska
7. T. Postler
8. S. Imai

Citations in the corpus

• Functionally Defective High-Density Lipoprotein: A New Therapeutic Target at the Crossroads of Dyslipidemia, Inflammation, and Atherosclerosis (2006, background): “The recently discovered orphan G-protein-coupled receptor (HM74) in man has been identified as the nicotinic acid receptor in adipose tissue (Tunaru et al., 2003).”
• The NAD+ precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet induced obesity (2012, neutral): “Interestingly, the mechanism of action of NA on VLDL/LDL and hepatic metabolism is not clear, as GPR109A is not expressed in the liver (Tunaru et al., 2003).”
• NAD+ metabolism and the control of energy homeostasis - a balancing act between mitochondria and the nucleus (2015, background): “However, the absence of GRP109A expression in the liver (Soga et al., 2003; Tunaru et al., 2003; Wise et al., 2003), a central hub for HDL and LDLmetabolism, also questions whether the effects of NA on blood lipids derive from GPR109A activation.”
• The Human Obesity Gene Map: The 2005 Update (2006, background): “31 GPR109A G-protein-coupled receptor 109a Absence of nicotinic acid-induced inhibition of free fatty acid release from adipocytes (407)”
• Multi-dimensional roles of ketone bodies in fuel metabolism, signaling, and therapeutics (2017, background): “Nonenzymatic nitration of tyrosine residues of SCOT also attenuates its activity, which has been reported in hearts of various diabetic mice models (Marcondes et al., 2001; Turko et al., 2001; Wang et al., 2010a).”
• Anatomical profiling of G protein-coupled receptor expression (2008, positive): “Hm74(Gpr109a), the ketone body receptor that is activated therapeutically by niacin to treat dyslipidemias (Soga et al., 2003;Tunaru et al., 2003;Wise et al., 2003) provides an interesting example.”
• Understanding the Holobiont: How microbial metabolites affect human health and shape the immune system (2017, background): “…of NLRP6 inflammasome activation Derived from hos produced primar salts by intestina microbiota interestingly, expresses OR51E2) (Brown et al., 2003; Fleischer et al., 2015; Le Poul et al., 2003; Nilsson et al., 2003; Shi et al., 2017; Tolhurst et al., 2012; Tunaru et al., 2003; Wise et al., 2003).”