ROLE FOR ADULT NEUROGENESIS IN SPATIAL LONG-TERM EMORY

By N. S. Hong, R. McDonaldb, M. WOJTOWICZa. 2005

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New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory? (2010, background): “, but not in studies using other knockdown methods to prevent neurogenesi”
Anatomical gradients of adult neurogenesis and activity: young neurons in the ventral dentate gyrus are activated by water maze training (2009, unknown): “…functional (Wang et al., 2000; Snyder et al., 2001; van Praag et al., 2002; Esposito et al., 2005; Ge et al., 2006) and contribute to hippocampus-dependent behaviors (Shors et al., 2001, 2002; Santarelli et al., 2003; Snyder et al., 2005; Saxe et al., 2006, 2007; Winocur et al., 2006).”
Adult neurogenesis modulates the hippocampus-dependent period of associative fear memory. (2009, background): “There are several studies examining maintenance of memory (Imayoshi et al., 2008; Snyder et al., 2005), but whether the continuous integration of new neurons into hippocampal circuits modifies, impairs, or strengthens pre-existing memory information is not well understood.”
Epigenetic Modulation of Seizure-Induced Neurogenesis and Cognitive Decline (2007, background): “Supporting a functional role for physiologically generated new granule cells is the finding that ablation of new neurons with cytostatic drugs or irradiation correlates with impairment in some hippocampus-dependent learning tasks (Shors et al., 2001, 2002; Snyder et al., 2005), although the specific”
Inhibition of neurogenesis interferes with hippocampus‐dependent memory function (2006, methodology): “These effects are in line with the previous studies (Snyder et al., 2005; Wang et al., 2005).”
Dentate gyrus-specific knockdown of adult neurogenesis impairs spatial and object recognition memory in adult rats. (2009, methodology): “in the water maze (using irradiation and MAM) (Shors et al. 2002; Meshi et al. 2006), others described substantial deficits in longterm retention (using irradiation [ Snyder et al. 2005 ] or diphtheria toxin-based ablation of new neurons [Imayoshi et al. 2008]) or even impairment in the acquisition ”
Effects of adult-generated granule cells on coordinated network activity in the dentate gyrus (2010, background): “…shown that neurogenesis may support hippocampal-dependent behaviors such as contextual fear conditioning (Saxe et al., 2006; Deng et al., 2009), specific Morris water maze paradigms (Snyder et al., 2005; Zhang et al., 2008; Deng et al., 2009), and spatial pattern separation (Clelland et al., 2009).”
Electroconvulsive seizure restores neurogenesis and hippocampus‐dependent fear memory after disruption by irradiation (2008, background): “The behavioral consequences of IRR exposure are also long lasting (Madsen et al., 2003; Rola et al., 2004; Snyder et al., 2005; Saxe et al., 2006; Winocur et al., 2006) and correlate with impairments in neurogenesis.”
Nuclear factor of activated T cells (NFATc4) is required for BDNF-dependent survival of adult-born neurons and spatial memory formation in the hippocampus (2012, methodology): “Next, mice underwent a reference memory version of the Morris water maze, which is among the most frequently used experimental paradigms for the functional assessment of adult neurogenesis (32).”
Temporal Discontiguity Is neither Necessary nor Sufficient for Learning-Induced Effects on Adult Neurogenesis (2006, background): “In contrast, depletion of new neurons does not affect spatial navigation learning (Shors et al., 2001; Madsen et al., 2003; Raber et al., 2004; Snyder et al., 2005), although there are effects on retention (Snyder et al., 2005).”
Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain (2008, background): “Ablation of newly formed neurons impairs spatial memory Although it has been suggested that hippocampal neurogenesis is involved in spatial memor”
Long-Term Potentiation Enhances Neurogenesis in the Adult Dentate Gyrus (2006, background): “…Bruel-Jungerman et al., 2005), physical exercise (van Praag et al., 1999), and specific hippocampal-dependent learning tasks (Gould et al., 1999; Snyder et al., 2005) can regulate neurogenic activity in the DG. Enrichment and voluntary running also facilitate hippocampal LTP and improve…”