Wnt signaling in osteoblasts and bone diseases.
By J. Westendorf, Rachel A. Kahler, T. Schroeder. Gene, 2004
845 citations recorded by the source corpus.
Subfields: Genetics, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/d6a87a2f52270fbeea6c81cadbf98815a5b4a7ae
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Genetics
- L. Bonewald
- Daniel S. Himmelstein
- Casey S. Greene
- Andrea Augello
- C. De Bari
- Daniel Chasman
- Sameer Quazi
In Molecular Biology
- E. Rosen
- L. Bonewald
- Casey S. Greene
- Olga G. Troyanskaya
- E. Eriksen
- Daniel S. Himmelstein
- Andrea Augello
- Kara Dolinski
Citations in the corpus
- Osteocytes, mechanosensing and Wnt signaling. (2008, background): “The Wnt pathway clearly plays an important role in bone cell differentiation, proliferation and apoptosis as shown by a number of studies (reviewed in [126,47,16]).”
- Understanding multicellular function and disease with human tissue-specific networks (2015, positive): “Numerous studies point to a pivotal role of LEF1 in osteoblast proliferation, maturation, function, and regeneration 37–39 , and potential involvement in bone disease 40,41 .”
- Cellular mechanisms of bone remodeling (2010, background): “Wnt signalling dominate osteoblast differentiation pathways and act via binding to a receptor complex consisting of LDL receptor-related protein 5 (LRP5) orLRP6 and one of ten Frizzled molecules [13].”
- Mechanisms underlying differential responses to FGF signaling. (2005, background): “In humans, loss of function mutations in LRP5, a Wnt co-receptor, cause osteoporosis-pseudoglioma, while LRP5 activating mutations are linked to several high bone mass syndromes [117].”
- Glucocorticoid-induced osteoporosis: pathophysiology and therapy (2007, background): “Wnt uses four known signaling pathways, but in skeletal cells the canonical Wnt/β-catenin signaling pathway operates [ 18 ].”
- The Regulation of Differentiation in Mesenchymal Stem Cells (2010, positive): “Wnt genes, a family of 19 genes in humans and mice, produce secreted proteins that, for their involvement in cell proliferation, differentiation, and apoptosis, are crucial in embryonic tissue development and in regeneration of adult tissues including bone (Westendorf et al., 2004).”
- Adipocyte differentiation from the inside out (2006, background): “Wnt signalling functions as an important regulator of mesenchymal-cell fat”